一组新的自然感染猩猩（侏儒黑猩猩）的嗜肝DNA病毒。
A new group of hepadnaviruses naturally infecting orangutans (Pongo pygmaeus).
作者信息
Warren K S, Heeney J L, Swan R A, Verschoor E J
机构信息
Division of Veterinary and Biomedical Sciences, Murdoch University, Western Australia, Australia.
出版信息
J Virol. 1999 Sep;73(9):7860-5. doi: 10.1128/JVI.73.9.7860-7865.1999.
Abstract
A high prevalence (42.6%) of hepatitis B virus (HBV) infection was suspected in 195 formerly captive orangutans due to a large number of serum samples which cross-reacted with human HBV antigens. It was assumed that such viral infections were contracted from humans during captivity. However, two wild orangutans were identified which were HBV surface antigen positive, indicating that HBV or related viruses may be occurring naturally in the orangutan populations. Sequence analyses of seven isolates revealed that orangutans were infected with hepadnaviruses but that these were clearly divergent from the six known human HBV genotypes and those of other nonhuman hepadnaviruses reported. Phylogenetic analyses revealed geographic clustering with Southeast Asian genotype C viruses and gibbon ape HBV. This implies a common origin of infection within this geographic region, with cross-species transmission of hepadnaviruses among hominoids.
摘要
由于大量血清样本与人类乙肝病毒（HBV）抗原发生交叉反应，在195只曾被圈养的红毛猩猩中怀疑有较高比例（42.6%）感染了乙肝病毒。据推测，此类病毒感染是在圈养期间从人类身上感染的。然而，鉴定出两只野生红毛猩猩乙肝病毒表面抗原呈阳性，这表明乙肝病毒或相关病毒可能在红毛猩猩种群中自然存在。对七个分离株的序列分析显示，红毛猩猩感染了嗜肝DNA病毒，但这些病毒明显不同于已知的六种人类乙肝病毒基因型以及所报道的其他非人类嗜肝DNA病毒的基因型。系统发育分析显示，与东南亚C基因型病毒和长臂猿乙肝病毒存在地理聚类。这意味着在该地理区域内存在共同的感染源，嗜肝DNA病毒在类人猿之间发生了跨物种传播。
相似文献
1
A new group of hepadnaviruses naturally infecting orangutans (Pongo pygmaeus).一组新的自然感染猩猩（侏儒黑猩猩）的嗜肝DNA病毒。
J Virol. 1999 Sep;73(9):7860-5. doi: 10.1128/JVI.73.9.7860-7865.1999.
2
Hepadnavirus infection in captive gibbons.圈养长臂猿中的嗜肝DNA病毒感染
J Virol. 2000 Mar;74(6):2955-9. doi: 10.1128/jvi.74.6.2955-2959.2000.
3
Prevalence, whole genome characterization and phylogenetic analysis of hepatitis B virus in captive orangutan and gibbon.圈养红毛猩猩和长臂猿中乙型肝炎病毒的流行率、全基因组特征及系统发育分析
J Med Primatol. 2008 Dec;37(6):277-89. doi: 10.1111/j.1600-0684.2008.00290.x. Epub 2008 May 2.
4
A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J.从一名日本患者体内分离出的一种与已知人类和猿类基因型不同的乙肝病毒基因变异体，暂定为新的J基因型。
J Virol. 2009 Oct;83(20):10538-47. doi: 10.1128/JVI.00462-09. Epub 2009 Jul 29.
5
Complete sequencing of a gibbon hepatitis B virus genome reveals a unique genotype distantly related to the chimpanzee hepatitis B virus.长臂猿乙型肝炎病毒基因组的完整测序揭示了一种与黑猩猩乙型肝炎病毒远缘相关的独特基因型。
Virology. 1996 Apr 1;218(1):214-23. doi: 10.1006/viro.1996.0181.
6
Tracing the evolutionary history of hepadnaviruses in terms of e antigen and middle envelope protein expression or processing.根据 e 抗原和中包膜蛋白的表达或加工情况，追踪 hepadnaviruses 的进化史。
Virus Res. 2020 Jan 15;276:197825. doi: 10.1016/j.virusres.2019.197825. Epub 2019 Nov 27.
7
Analysis of two genomic variants of orang-utan hepadnavirus and their relationship to other primate hepatitis B-like viruses.红毛猩猩嗜肝DNA病毒两种基因组变体分析及其与其他灵长类乙型肝炎样病毒的关系。
J Gen Virol. 2001 Apr;82(Pt 4):893-897. doi: 10.1099/0022-1317-82-4-893.
8
Full-genome sequence analyses of hepatitis B virus (HBV) strains recovered from chimpanzees infected in the wild: implications for an origin of HBV.对从野生感染黑猩猩体内分离出的乙型肝炎病毒（HBV）毒株进行全基因组序列分析：对HBV起源的启示
Virology. 2000 Feb 1;267(1):58-64. doi: 10.1006/viro.1999.0102.
9
Extensive diversity and evolution of hepadnaviruses in bats in China.中国蝙蝠中 hepadnaviruses 的广泛多样性和进化。
Virology. 2018 Jan 15;514:88-97. doi: 10.1016/j.virol.2017.11.005. Epub 2017 Nov 16.
10
Genetic characterization of hepadnaviruses associated with histopathological changes in the liver of duck and goose embryos.与鸭和鹅胚胎肝脏组织病理学变化相关的嗜肝DNA病毒的基因特征分析。
Vet Microbiol. 2014 Dec 5;174(3-4):302-308. doi: 10.1016/j.vetmic.2014.09.026. Epub 2014 Oct 14.
引用本文的文献
1
Origins and Evolution of the Primate Hepatitis B Virus.灵长类动物乙型肝炎病毒的起源与进化
Front Microbiol. 2021 May 24;12:653684. doi: 10.3389/fmicb.2021.653684. eCollection 2021.
2
Molecular detection and characterisation of Domestic Cat Hepadnavirus (DCH) from blood and liver tissues of cats in Malaysia.马来西亚猫血液和肝脏组织中家猫嗜肝DNA病毒（DCH）的分子检测与特征分析
BMC Vet Res. 2021 Jan 6;17(1):9. doi: 10.1186/s12917-020-02700-0.
3
Novel Genetic Rearrangements Termed "Structural Variation Polymorphisms" Contribute to the Genetic Diversity of Orthohepadnaviruses.新型遗传重排被称为“结构变异多态性”，有助于正嗜肝 DNA 病毒的遗传多样性。
Viruses. 2019 Sep 17;11(9):871. doi: 10.3390/v11090871.
4
Evaluation of HBV-Like Circulation in Wild and Farm Animals from Brazil and Uruguay.评估巴西和乌拉圭野生和养殖动物中的乙型肝炎病毒样循环。
Int J Environ Res Public Health. 2019 Jul 26;16(15):2679. doi: 10.3390/ijerph16152679.
5
Evolutionary biology of human hepatitis viruses.人类肝炎病毒的进化生物学。
J Hepatol. 2019 Mar;70(3):501-520. doi: 10.1016/j.jhep.2018.11.010. Epub 2018 Nov 23.
6
Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis.过氧化物酶体增殖物激活受体 γ 辅激活因子家族成员竞争性调节乙型肝炎病毒的生物合成。
Virology. 2019 Jan 2;526:214-221. doi: 10.1016/j.virol.2018.10.027. Epub 2018 Nov 10.
7
Prevalence of Cryptosporidium spp., Enterocytozoon bieneusi, Encephalitozoon spp. and Giardia intestinalis in Wild, Semi-Wild and Captive Orangutans (Pongo abelii and Pongo pygmaeus) on Sumatra and Borneo, Indonesia.印度尼西亚苏门答腊岛和婆罗洲野生、半野生及圈养猩猩（苏门答腊猩猩和婆罗洲猩猩）中隐孢子虫属、比氏肠微孢子虫、脑胞内原虫属和肠贾第虫的流行情况
PLoS One. 2016 Mar 31;11(3):e0152771. doi: 10.1371/journal.pone.0152771. eCollection 2016.
8
Origins and Evolution of Hepatitis B Virus and Hepatitis D Virus.乙型肝炎病毒和丁型肝炎病毒的起源与进化
Cold Spring Harb Perspect Med. 2016 Jan 4;6(1):a021360. doi: 10.1101/cshperspect.a021360.
9
The chimpanzee model for hepatitis B virus infection.乙型肝炎病毒感染的黑猩猩模型。
Cold Spring Harb Perspect Med. 2015 Jun 1;5(6):a021469. doi: 10.1101/cshperspect.a021469.
10
Molecular biology of hepatitis B virus infection.乙型肝炎病毒感染的分子生物学
Virology. 2015 May;479-480:672-86. doi: 10.1016/j.virol.2015.02.031. Epub 2015 Mar 7.
本文引用的文献
1
A pathogenic threshold of virus load defined in simian immunodeficiency virus- or simian-human immunodeficiency virus-infected macaques.在感染猿猴免疫缺陷病毒或猿猴-人类免疫缺陷病毒的猕猴中定义的病毒载量致病阈值。
J Virol. 1998 Dec;72(12):10281-5. doi: 10.1128/JVI.72.12.10281-10285.1998.
2
Wild primate populations in emerging infectious disease research: the missing link?新兴传染病研究中的野生灵长类动物种群：缺失的环节？
Emerg Infect Dis. 1998 Apr-Jun;4(2):149-58. doi: 10.3201/eid0402.980202.
3
Seroprevalence of specific viral infections in confiscated orangutans (Pongo pygmaeus).
J Med Primatol. 1998 Feb;27(1):33-7. doi: 10.1111/j.1600-0684.1998.tb00066.x.
4
Isolation of a hepadnavirus from the woolly monkey, a New World primate.从新世界灵长类动物绒毛猴中分离出一种嗜肝DNA病毒。
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5757-61. doi: 10.1073/pnas.95.10.5757.
5
Antigenic diversity of hepatitis B virus strains of genotype F in Amerindians and other population groups from Venezuela.委内瑞拉美洲印第安人和其他人群中F基因型乙型肝炎病毒株的抗原多样性。
J Clin Microbiol. 1998 Mar;36(3):648-51. doi: 10.1128/JCM.36.3.648-651.1998.
6
Subtypes, genotypes and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S-gene.S基因序列变异性所反映的乙型肝炎病毒的亚型、基因型及分子流行病学
Intervirology. 1995;38(1-2):24-34. doi: 10.1159/000150411.
7
Complete sequencing of a gibbon hepatitis B virus genome reveals a unique genotype distantly related to the chimpanzee hepatitis B virus.长臂猿乙型肝炎病毒基因组的完整测序揭示了一种与黑猩猩乙型肝炎病毒远缘相关的独特基因型。
Virology. 1996 Apr 1;218(1):214-23. doi: 10.1006/viro.1996.0181.
8
Prevention of acute and chronic liver disease through immunization: hepatitis B and beyond.通过免疫接种预防急慢性肝病：乙型肝炎及其他。
J Infect Dis. 1993 Jul;168(1):9-14. doi: 10.1093/infdis/168.1.9.
9
The complete nucleotide sequence of a pre-core mutant of hepatitis B virus implicated in fulminant hepatitis and its biological characterization in chimpanzees.与暴发性肝炎相关的乙型肝炎病毒前核心突变体的完整核苷酸序列及其在黑猩猩中的生物学特性。
Virology. 1993 May;194(1):263-76. doi: 10.1006/viro.1993.1257.
10
Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen.不同地理来源的乙型肝炎病毒株的遗传相关性及表面抗原一级结构的自然变异
J Gen Virol. 1993 Jul;74 ( Pt 7):1341-8. doi: 10.1099/0022-1317-74-7-1341.
Zotero 插件