Miki M, Ohtake N, Hasumi M, Ohi M, Moriyama S
Department of Urology, Asama General Hospital, Saku, Nagano, Japan.
Int J Urol. 1999 Jul;6(7):377-80. doi: 10.1046/j.1442-2042.1999.00078.x.
A case of testicular typical seminoma associated with bilateral undescended testes in Down's syndrome is reported. A 42-year-old institutionalized male patient developed left testicular seminoma with retroperitoneal metastasis.
METHODS/RESULTS: Neither adjuvant chemotherapy nor radiotherapy were performed due to his severe mental retardation. He died as a result of the cancer 2 years after a left radical orchiectomy and an autopsy was carried out.
Recently an increase in the incidence of the association of testicular tumors and Down's syndrome has been repeatedly documented. Thirty-six cases of testicular tumors associated with Down's syndrome have been reported and of these 17.1% had cryptorchidism. This is a much lower percentage considering the high risk of cryptorchidism in males with Down's syndrome. The relationship between testicular germ cell tumors associated with cryptorchidism and Down's syndrome is discussed.
报告1例唐氏综合征合并双侧隐睾的睾丸典型精原细胞瘤病例。一名42岁的男性住院患者发生左侧睾丸精原细胞瘤并伴有腹膜后转移。
方法/结果：由于其严重智力发育迟缓，未进行辅助化疗和放疗。在接受左侧根治性睾丸切除术后2年，他因癌症死亡，并进行了尸检。
最近，睾丸肿瘤与唐氏综合征关联的发病率增加已被多次记录。已报道36例与唐氏综合征相关的睾丸肿瘤病例，其中17.1%患有隐睾症。考虑到唐氏综合征男性患隐睾症的高风险，这一比例要低得多。本文讨论了与隐睾症相关的睾丸生殖细胞肿瘤和唐氏综合征之间的关系。
