Kuroda Naoto, Amano Shinji, Shiotsu Tomoyuki, Tamura Masato, Hes Ondrej, Michal Michal, Lee Gang-Hong
Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi City, Kochi, Japan.
APMIS. 2007 Nov;115(11):1292-5. doi: 10.1111/j.1600-0643.2007.00497.x.
We here present a case of mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome. A 20-year-old Japanese man with a mass in the left inguinal region underwent orchidectomy as a left testicular tumor was suspected. Histology showed a mixed germ-cell tumor with embryonal carcinoma and yolk sac tumor with syncytiotrophoblastic giant cells occurring in a cryptorchid testis. Chromosomal analysis of peripheral lymphocytes disclosed a karyotype of 47,XY,+21[20]. Our case provides further evidence that these three conditions-Down's syndrome, cryptorchidism and testicular germ cell tumor-may be closely associated. To our knowledge this is the first case of mixed germ cell tumor arising in a patient with Down's syndrome and cryptorchidism.
我们在此报告一例患有隐睾症和唐氏综合征的成年男性混合性睾丸生殖细胞肿瘤病例。一名20岁的日本男性因左侧腹股沟区有肿块，怀疑左侧睾丸肿瘤而接受了睾丸切除术。组织学检查显示为混合性生殖细胞肿瘤，伴有胚胎癌和卵黄囊瘤，并在隐睾中出现合体滋养层巨细胞。外周血淋巴细胞的染色体分析显示核型为47,XY,+21[20]。我们的病例进一步证明，唐氏综合征、隐睾症和睾丸生殖细胞肿瘤这三种情况可能密切相关。据我们所知，这是首例在患有唐氏综合征和隐睾症的患者中发生的混合性生殖细胞肿瘤病例。
