Dieckmann K P, Rübe C, Henke R P
Urologische Abteilung, Albertinen-Krankenhaus Hamburg and Institut für Pathologie, Universitätskrankenhaus Eppendorf, Germany.
J Urol. 1997 May;157(5):1701-4.
We present additional clinical evidence for the suspected association of Down's syndrome and testicular germ cell tumors.
Four cases of Down's syndrome and testicular cancer are reported. The literature was reviewed for previous cases and analysis regarding common features.
The 4 patients were 29 to 35 years old and had clinical stage I seminoma of the testis. Two patients received prophylactic abdominal radiotherapy, 1 is being followed and 1 received adjuvant carboplatin treatment. There was no relapse at followup of 1 to 8 years. One patient also had contralateral cryptorchidism. A total of 16 cases with the association of Down's syndrome and testicular germ cell cancer was documented previously.
Evidence for the suspected association of Down's syndrome and testicular cancer is now accumulating. Etiologically it is suspected that, along with genetically determined malformations in many other organs in trisomy 21, the gonads also undergo maldevelopment, thus creating the conditions for step 1 of germ cell tumor oncogenesis in utero. Physicians caring for patients with Down's syndrome should be aware of the possible association with testicular neoplasms.
我们为唐氏综合征与睾丸生殖细胞肿瘤之间的疑似关联提供更多临床证据。
报告了4例唐氏综合征合并睾丸癌的病例。回顾文献以查找先前病例并分析共同特征。
4例患者年龄在29至35岁之间，患有临床I期睾丸精原细胞瘤。2例患者接受了预防性腹部放疗，1例正在接受随访，1例接受了辅助性卡铂治疗。在1至8年的随访中无复发情况。1例患者还患有对侧隐睾症。先前共记录了16例唐氏综合征与睾丸生殖细胞癌相关的病例。
唐氏综合征与睾丸癌之间疑似关联的证据正在不断积累。从病因学角度怀疑，与21三体综合征中许多其他器官的基因决定的畸形一样，性腺也会发生发育异常，从而为子宫内生殖细胞肿瘤发生的第一步创造条件。照顾唐氏综合征患者的医生应意识到其与睾丸肿瘤可能存在的关联。
