尽管银屑病患者血清中的胆红素、生育酚和尿酸水平升高，但其总抗氧化能力正常。
Total antioxidative capacity is normal in sera from psoriasis patients despite elevated bilirubin, tocopherol and urate levels.
作者信息
Severin E, Nave B, Ständer M, Ott R, Traupe H
机构信息
Institut für Strahlenbiologie der Universität, Münster, Germany.
出版信息
Dermatology. 1999;198(4):336-9. doi: 10.1159/000018171.
BACKGROUND
Psoriasis is a chronic inflammatory skin disease. Reactive oxygen species are thought to play a critical role in inflammation and are scavenged by antioxidants.
OBJECTIVE
We wanted to know whether the total antioxidative capacity or single antioxidative components in sera from psoriasis patients are decreased.
MATERIAL AND METHODS
Well-known antioxidants of the serum were measured using commercial kits or determined by HPLC in the sera of 33 inpatients with severe psoriasis and in 36 healthy control persons. The total antioxidative capacity was measured using the ability of endogenous antioxidants to scavenge the 2, 2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation.
RESULTS
Several single antioxidative components were slightly elevated when considered groupwise, namely tocopherol (p = 0.001), bilirubin (p = 0.001) and urate which was increased over controls by about 33% (p= 0.01). Other parameters such as total protein and thiol content and ascorbic acid did not differ from controls.
CONCLUSION
To our surprise the total antioxidative activity was normal in sera from psoriasis patients although some components such as urate were even elevated.
背景
银屑病是一种慢性炎症性皮肤病。活性氧被认为在炎症中起关键作用，并被抗氧化剂清除。
目的
我们想了解银屑病患者血清中的总抗氧化能力或单一抗氧化成分是否降低。
材料与方法
使用商业试剂盒或通过高效液相色谱法测定33例重度银屑病住院患者和36例健康对照者血清中著名的抗氧化剂。总抗氧化能力通过内源性抗氧化剂清除2, 2'-偶氮二(3-乙基苯并噻唑啉-6-磺酸)自由基阳离子的能力来测定。
结果
从分组来看，几种单一抗氧化成分略有升高，即生育酚（p = 0.001）、胆红素（p = 0.001）和尿酸盐，其含量比对照组增加约33%（p = 0.01）。其他参数如总蛋白、硫醇含量和抗坏血酸与对照组无差异。
结论
令我们惊讶的是，银屑病患者血清中的总抗氧化活性正常，尽管尿酸盐等一些成分甚至有所升高。
Zotero 插件