Chawla S, Mohanti B K, Rakshak M, Saxena S, Rath G K, Bahadur S
Department of Radiation Oncology (Institute Rotary Cancer Hospital), All India Institute of Medical Sciences, New Delhi, India.
Qual Life Res. 1999;8(1-2):73-8. doi: 10.1023/a:1026476928283.
The study was undertaken to evaluate physical, psychological and functional aspects in quality of life (QoL) assessment prospectively in biopsy-proven head and neck cancer patients receiving radical radiotherapy. Fifty male patients were assessed using Karnofsky's Performance Status (KPS), Beck's Depression Inventory (BDI) and the Functional Living Index-Cancer (FLIC). Patient questionnaires were completed before radiotherapy, during 3-4 weeks of radiotherapy and 3 months after radiotherapy. Before the start of radiotherapy, KPS was 91 +/- 10.26, FLIC was 129.98 +/- 33.41 and BDI was 7.10 +/- 4.57. This indicated good performance and functional status with lower depression. In weeks 3-4 of radiotherapy, KPS (71.00 +/- 20.12) and FLIC (81.34 +/- 45.23) decreased, while BDI (16.56 +/- 9.01) increased, indicating impairment in QoL. Three months after radiotherapy, KPS (78.37 +/- 23.0), FLIC (119.51 +/- 43.62) and BDI (9.02 +/- 7.81) improved but were not restored to pre-treatment levels. When patients were scheduled for radical radiotherapy, maximum deterioration in QoL was seen in weeks 3-4. This is the time when maximum supportive care and psychologic counselling is required.
本研究旨在对经活检证实的头颈部癌患者接受根治性放疗后的生活质量（QoL）评估中的身体、心理和功能方面进行前瞻性评估。使用卡诺夫斯基功能状态量表（KPS）、贝克抑郁量表（BDI）和癌症功能生活指数（FLIC）对50名男性患者进行评估。在放疗前、放疗3 - 4周期间和放疗后3个月完成患者问卷。放疗开始前，KPS为91±10.26，FLIC为129.98±33.41，BDI为7.10±4.57。这表明患者表现良好，功能状态良好，抑郁程度较低。在放疗的第3 - 4周，KPS（71.00±20.12）和FLIC（81.34±45.23）下降，而BDI（16.56±9.01）上升，表明生活质量受损。放疗后3个月，KPS（78.37±23.0）、FLIC（119.51±43.62）和BDI（9.02±7.81）有所改善，但未恢复到治疗前水平。当患者安排进行根治性放疗时，生活质量在第3 - 4周出现最大程度的恶化。这是最需要最大程度的支持性护理和心理辅导的时候。
