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对谷氨酸-丙氨酸-酪氨酸三元共聚物免疫应答的遗传控制。I. 品系间和种间交叉反应性独特型。

Genetic control of the immune response to the GAT terpolymer. I. Interstrain and interspecies cross-reactive idiotype.

作者信息

Thèze J, Moreau J L

出版信息

Ann Immunol (Paris). 1978 Jul-Sep;129 C(5):721-6.

PMID:104654
Abstract

An antiidiotypic antiserum specific for the GAT antibodies of BALB/c mice has been obtained in rabbits. This serum recognizes the GAT idiotype of 13 inbred strains of mice as well as the GAT idiotype present in sera of guinea-pigs, rats and rabbits immunized with GAT. Such an antiidiotypic antiserum should serve as a good reagent to detect putative idiotypic determinants on GAT-specific suppressor factor.

摘要

在兔子体内获得了一种针对BALB/c小鼠GAT抗体的抗独特型抗血清。该血清可识别13个近交系小鼠的GAT独特型，以及用GAT免疫的豚鼠、大鼠和兔子血清中存在的GAT独特型。这种抗独特型抗血清应可作为一种很好的试剂，用于检测GAT特异性抑制因子上假定的独特型决定簇。

相似文献

1
Genetic control of the immune response to the GAT terpolymer. I. Interstrain and interspecies cross-reactive idiotype.对谷氨酸-丙氨酸-酪氨酸三元共聚物免疫应答的遗传控制。I. 品系间和种间交叉反应性独特型。
Ann Immunol (Paris). 1978 Jul-Sep;129 C(5):721-6.
2
Genetic control of the immune response to the L-Glu60-L-Ala30-L-Tyr10 (GAT) terpolymer. V. Three types of idiotypic specificities on BALB/c anti-GAT antibodies.对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）三元共聚物免疫应答的遗传控制。V. BALB/c抗GAT抗体上的三种独特型特异性
Eur J Immunol. 1981 Jun;11(6):493-8. doi: 10.1002/eji.1830110610.
3
Genetic control of the immune response to the terpolymer L-glutamic acid(60)-L-alanine(30)-L-tyrosine(10)(GAT). II. Characterization of a cross-reactive idiotype associated with anti-GAT antibodies from responder and nonresponder mice.对三元共聚物L-谷氨酸（60）-L-丙氨酸（30）-L-酪氨酸（10）（GAT）免疫应答的遗传控制。II. 与来自应答和不应答小鼠的抗GAT抗体相关的交叉反应性独特型的特征分析。
Eur J Immunol. 1979 Apr;9(4):294-301. doi: 10.1002/eji.1830090409.
4
Idiotypic analysis of antibodies to poly(Glu60Ala30Tyr10): interstrain and interspecies idiotypic crossreactions.针对聚（Glu60Ala30Tyr10）抗体的独特型分析：品系间和种间独特型交叉反应
Proc Natl Acad Sci U S A. 1978 Dec;75(12):6192-6. doi: 10.1073/pnas.75.12.6192.
5
Idiotypic analysis of anti-GAT antibodies. V. Distribution of an interspecies cross-reactive idiotype.抗GAT抗体的独特型分析。V. 种间交叉反应独特型的分布
J Immunol. 1979 Aug;123(2):877-83.
6
Idiotypic analysis of anti-GAT antibodies. VIII. Comparison of interstrain and allotype-associated idiotypic specificities.抗GAT抗体的独特型分析。VIII. 不同品系间及与同种异型相关的独特型特异性比较。
J Immunol. 1981 Jan;126(1):177-82.
7
Genetic control of the immune response to the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine10 (GAT). III. Restricted heterogeneity of the anti-GAT response from BALB/c responder mice.对三元共聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）免疫反应的遗传控制。III. BALB/c反应小鼠抗GAT反应的有限异质性。
Eur J Immunol. 1979 Dec;9(12):922-8. doi: 10.1002/eji.1830091203.
8
Analysis of a major rat idiotype associated with Anti-GAT antibodies.与抗谷氨酸脱羧酶（GAD）抗体相关的主要大鼠独特型分析。
Mol Immunol. 1982 Sep;19(9):1139-47. doi: 10.1016/0161-5890(82)90324-8.
9
Characterization of two monoclonal idiotype-binding suppressor T cell factors specific for the antibody response to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).针对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）抗体反应的两种单克隆独特型结合抑制性T细胞因子的特性分析。
J Immunol. 1986 Dec 15;137(12):3709-16.
10
Idiotypic analysis of antibodies against the terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). IV. Induction of CGAT idiotype following immunization with various synthetic polymers containing glutamic acid and tyrosine.针对三元共聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）抗体的独特型分析。IV. 用含谷氨酸和酪氨酸的各种合成聚合物免疫后CGAT独特型的诱导。
Eur J Immunol. 1979 Jul;9(7):553-60. doi: 10.1002/eji.1830090711.

引用本文的文献

1
Recurrent idiotopes and internal images.复发性独特型位和内影像
EMBO J. 1982;1(2):243-7. doi: 10.1002/j.1460-2075.1982.tb01154.x.
2
Analysis of antibody diversity: V-D-J mRNA nucleotide sequence of four anti-GAT monoclonal antibodies. A paucigene system using alternate D-J recombinations to generate functionally similar hypervariable regions.抗体多样性分析：四种抗GAT单克隆抗体的V-D-J mRNA核苷酸序列。一种利用交替D-J重组产生功能相似高变区的寡基因系统。
EMBO J. 1983;2(6):867-72. doi: 10.1002/j.1460-2075.1983.tb01515.x.
3
V kappa gene family in (Glu60 Ala30 Tyr10)n (GAT)-specific antibodies that express CGAT (or pGAT) public idiotypic specificities. Protein and mRNA sequencing of eight monoclonal V kappa chains.
表达CGAT（或pGAT）公共独特型特异性的（Glu60 Ala30 Tyr10）n（GAT）特异性抗体中的Vκ基因家族。八条单克隆Vκ链的蛋白质和mRNA测序。
J Exp Med. 1983 Nov 1;158(5):1415-27. doi: 10.1084/jem.158.5.1415.
4
Immunoglobulin diversity: analysis of the germ-line VH gene repertoire of the murine anti-GAT response.免疫球蛋白多样性：对小鼠抗GAT反应的种系VH基因库的分析。
Nucleic Acids Res. 1983 Jun 25;11(12):4007-17. doi: 10.1093/nar/11.12.4007.
5
Structural bases for public idiotypic specificities of monoclonal antibodies directed against poly(Glu60Ala30Tyr10) and poly(Glu60Ala40) random copolymers.针对聚（Glu60Ala30Tyr10）和聚（Glu60Ala40）无规共聚物的单克隆抗体的公共独特型特异性的结构基础
Proc Natl Acad Sci U S A. 1983 May;80(10):3040-4. doi: 10.1073/pnas.80.10.3040.
6
Interstrain conservation of the murine GAT-specific antibody V kappa repertoire as analyzed at the germline gene level.在种系基因水平分析的小鼠GAT特异性抗体Vκ基因库的品系间保守性。
EMBO J. 1983;2(10):1771-6. doi: 10.1002/j.1460-2075.1983.tb01656.x.
7
The idiotypic network and the internal image: possible regulation of a germ-line network by paucigene encoded Ab2 (anti-idiotypic) antibodies in the GAT system.独特型网络与内影像：在GAT系统中，寡基因编码的Ab2（抗独特型）抗体对种系网络的可能调控。
EMBO J. 1985 Dec 30;4(13B):3681-8. doi: 10.1002/j.1460-2075.1985.tb04135.x.
8
Genetic basis for expression of the idiotypic network. One unique Ig VH germline gene accounts for the major family of Ab1 and Ab3 (Ab1') antibodies of the GAT system.独特型网络表达的遗传基础。一个独特的Ig VH种系基因构成了GAT系统中Ab1和Ab3（Ab1'）抗体的主要家族。
J Exp Med. 1986 Mar 1;163(3):573-87. doi: 10.1084/jem.163.3.573.