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针对聚（Glu60Ala30Tyr10）抗体的独特型分析：品系间和种间独特型交叉反应

Idiotypic analysis of antibodies to poly(Glu60Ala30Tyr10): interstrain and interspecies idiotypic crossreactions.

作者信息

Ju S T, Benacerraf B, Dorf M E

出版信息

Proc Natl Acad Sci U S A. 1978 Dec;75(12):6192-6. doi: 10.1073/pnas.75.12.6192.

DOI:10.1073/pnas.75.12.6192
PMID:282636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC393145/
Abstract

A common idiotype was defined by a guinea pig anti-idiotypic antiserum made against D1.LP antibodies specific to the synthetic terpolymer poly(Glu60Ala30Tyr10), referred to as GAT. This idiotype was found in the anti-GAT antibodies of all individuals of all inbred strains of mice tested. Due to its common (C) occurrence in the anti-GAT antibodies of all mouse strains, it was termed the CGAT idiotype. The presence of CGAT idiotype in mice is independent of the expression of various Ig-1, H-2, or Vg genetic markers. In contrast, antibodies produced in response to the crossreactive poly(Glu60-Ala40), termed GA, bound to the GAT ligand but did not bear the CGAT idiotype. This suggests that GAT, although bearing GA determinants, preferentially stimulates clones of CGAT idiotype. Some of the CGAT idiotypic specificities were also identified in sera of WF inbred rats after immunization with GAT. However, no significant levels of CGAT idiotype were detected in LEW rats, F344 rats, guinea pigs, or rabbits, although measurable quantities of anti-GAT antibody were present.

摘要

一种常见独特型是由针对合成三元共聚物聚（Glu60Ala30Tyr10）（称为GAT）的D1.LP抗体产生的豚鼠抗独特型抗血清所定义。在所有测试的近交系小鼠个体的抗GAT抗体中都发现了这种独特型。由于其在所有小鼠品系的抗GAT抗体中普遍（C）存在，故将其称为CGAT独特型。小鼠中CGAT独特型的存在与各种Ig-1、H-2或Vg基因标记的表达无关。相反，针对交叉反应性聚（Glu60-Ala40）（称为GA）产生的抗体与GAT配体结合，但不具有CGAT独特型。这表明GAT虽然带有GA决定簇，但优先刺激CGAT独特型的克隆。在用GAT免疫后的WF近交系大鼠血清中也鉴定出了一些CGAT独特型特异性。然而，在LEW大鼠、F344大鼠、豚鼠或兔子中未检测到显著水平的CGAT独特型，尽管存在可测量量的抗GAT抗体。

相似文献

1
Idiotypic analysis of antibodies to poly(Glu60Ala30Tyr10): interstrain and interspecies idiotypic crossreactions.针对聚（Glu60Ala30Tyr10）抗体的独特型分析：品系间和种间独特型交叉反应
Proc Natl Acad Sci U S A. 1978 Dec;75(12):6192-6. doi: 10.1073/pnas.75.12.6192.
2
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Analysis of the cross-reactive immune suppression induced by the random copolymers L-glutamic acid50-L-tyrosine50 (GT), L-glutamic acid60-L-alanine40 and L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).对随机共聚物L-谷氨酸50-L-酪氨酸50（GT）、L-谷氨酸60-L-丙氨酸40和L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）诱导的交叉反应性免疫抑制的分析。
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Proc Natl Acad Sci U S A. 1976 Jun;73(6):2096-100. doi: 10.1073/pnas.73.6.2096.
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Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing.等电聚焦揭示的小鼠免疫球蛋白轻链的遗传多态性
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Idiotypic analysis of anti-GAT antibodies. I. Presence of common idiotypic specificities in both responder and nonresponder mice.抗GAT抗体的独特型分析。I. 应答和非应答小鼠中共同独特型特异性的存在。
J Immunol. 1978 Sep;121(3):1034-9.

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