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1
Idiotypic analysis of antibodies to poly(Glu60Ala30Tyr10): interstrain and interspecies idiotypic crossreactions.针对聚（Glu60Ala30Tyr10）抗体的独特型分析：品系间和种间独特型交叉反应
Proc Natl Acad Sci U S A. 1978 Dec;75(12):6192-6. doi: 10.1073/pnas.75.12.6192.
2
Idiotypic analysis of monoclonal antibodies to poly(Glu60Ala30Tyr10).针对聚（Glu60Ala30Tyr10）的单克隆抗体的独特型分析
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2942-6. doi: 10.1073/pnas.76.6.2942.
3
Idiotypic analysis of hybridoma antibodies to branched synthetic polymer (Tyr, Glu)-Ala-Lys: idiotypic relationship with antibodies to linear random polymer (Glu60, Ala30, Tyr10).针对支链合成聚合物（酪氨酸、谷氨酸）-丙氨酸-赖氨酸的杂交瘤抗体的独特型分析：与针对线性无规聚合物（谷氨酸60、丙氨酸30、酪氨酸10）抗体的独特型关系
J Immunol. 1982 Feb;128(2):545-50.
4
Idiotypic analysis of anti-GAT antibodies. VIII. Comparison of interstrain and allotype-associated idiotypic specificities.抗GAT抗体的独特型分析。VIII. 不同品系间及与同种异型相关的独特型特异性比较。
J Immunol. 1981 Jan;126(1):177-82.
5
Idiotypic analysis of antibodies against the terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). IV. Induction of CGAT idiotype following immunization with various synthetic polymers containing glutamic acid and tyrosine.针对三元共聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）抗体的独特型分析。IV. 用含谷氨酸和酪氨酸的各种合成聚合物免疫后CGAT独特型的诱导。
Eur J Immunol. 1979 Jul;9(7):553-60. doi: 10.1002/eji.1830090711.
6
Idiotypic analysis of anti-GAT antibodies. III. Determinant specificity and immunoglobulin class distribution of CGAT idiotype.抗GAT抗体的独特型分析。III. CGAT独特型的决定簇特异性和免疫球蛋白类别分布
J Immunol. 1979 Mar;122(3):1054-8.
7
Genetic control of the immune response to the GAT terpolymer. I. Interstrain and interspecies cross-reactive idiotype.对谷氨酸-丙氨酸-酪氨酸三元共聚物免疫应答的遗传控制。I. 品系间和种间交叉反应性独特型。
Ann Immunol (Paris). 1978 Jul-Sep;129 C(5):721-6.
8
Analysis of a major rat idiotype associated with Anti-GAT antibodies.与抗谷氨酸脱羧酶（GAD）抗体相关的主要大鼠独特型分析。
Mol Immunol. 1982 Sep;19(9):1139-47. doi: 10.1016/0161-5890(82)90324-8.
9
Fine specificity of antibodies to poly(Glu60Ala30Tyr10) produced by hybrid cell lines.杂交细胞系产生的针对聚（Glu60Ala30Tyr10）抗体的精细特异性。
Proc Natl Acad Sci U S A. 1979 May;76(5):2425-9. doi: 10.1073/pnas.76.5.2425.
10
Immunoselection of B cell hybridomas with anti-idiotypic antisera to study the role of heavy and light chains for idiotype expression and antibody activity.用抗独特型抗血清对B细胞杂交瘤进行免疫选择，以研究重链和轻链在独特型表达及抗体活性中的作用。
J Immunol. 1984 May;132(5):2485-90.

引用本文的文献

1
Recurrent idiotopes and internal images.复发性独特型位和内影像
EMBO J. 1982;1(2):243-7. doi: 10.1002/j.1460-2075.1982.tb01154.x.
2
Regulation of immune responses by I-J gene products. II. Presence of Both I-Jb and I-Jk suppressor factors in (nonsuppressor x nonsuppressor) F1 mice.I-J基因产物对免疫反应的调节。II. （非抑制性×非抑制性）F1小鼠中I-Jb和I-Jk抑制因子的存在
J Exp Med. 1982 Apr 1;155(4):955-67. doi: 10.1084/jem.155.4.955.
3
Helper and suppressor T cell factors.辅助性和抑制性T细胞因子。
Springer Semin Immunopathol. 1980 May;3(1):93-127. doi: 10.1007/BF00199927.
4
Linkage of murine (T,G)-A--L-specific idiotypic determinants to the heavy chain constant region allotypic markers.小鼠（T，G）-A--L特异性独特型决定簇与重链恒定区同种异型标记的连锁关系。
Immunogenetics. 1980;11(2):191-8. doi: 10.1007/BF01567784.
5
Genetic control of a shared idiotype among antibodies directed to distinct specificities.针对不同特异性的抗体之间共享独特型的遗传控制。
J Exp Med. 1980 Jul 1;152(1):170-82. doi: 10.1084/jem.152.1.170.
6
A major anti-myoglobin idiotype. Influence of H-2-linked Ir genes on idiotype expression.一种主要的抗肌红蛋白独特型。H-2连锁免疫反应基因对独特型表达的影响。
J Exp Med. 1984 Sep 1;160(3):659-78. doi: 10.1084/jem.160.3.659.
7
The role of I-J and Igh determinants on F1-derived suppressor factor in controlling restriction specificity.I-J和Igh决定簇在F1衍生抑制因子控制限制特异性中的作用。
J Exp Med. 1983 Nov 1;158(5):1428-43. doi: 10.1084/jem.158.5.1428.
8
T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segments.识别相同抗原的T细胞和B细胞不会转录相似的重链可变区基因片段。
J Exp Med. 1983 Jul 1;158(1):192-209. doi: 10.1084/jem.158.1.192.
9
Structural bases for public idiotypic specificities of monoclonal antibodies directed against poly(Glu60Ala30Tyr10) and poly(Glu60Ala40) random copolymers.针对聚（Glu60Ala30Tyr10）和聚（Glu60Ala40）无规共聚物的单克隆抗体的公共独特型特异性的结构基础
Proc Natl Acad Sci U S A. 1983 May;80(10):3040-4. doi: 10.1073/pnas.80.10.3040.
10
The polyclonal expression of immunoglobulin variable region determinants on the membrane of B cells and their precursors.免疫球蛋白可变区决定簇在B细胞及其前体细胞表面的多克隆表达。
Springer Semin Immunopathol. 1980 Aug;3(2):171-211. doi: 10.1007/BF02053975.

本文引用的文献

1
Antigenicity of polypeptides (poly alpha amino acids). XV. Studies on the immunogenicity of synthetic polypeptides in mice.多肽（聚α-氨基酸）的抗原性。第十五部分。小鼠体内合成多肽免疫原性的研究。
J Exp Med. 1965 Oct 1;122(4):665-71. doi: 10.1084/jem.122.4.665.
2
A genetic marker in the variable region of light chains of mouse immunoglobulins.小鼠免疫球蛋白轻链可变区中的一种遗传标记。
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1192-9. doi: 10.1073/pnas.67.3.1192.
3
Mapping the H-2-linked genes governing, respectively, the immune responses to a glutamic acid-alanine-tyrosine copolymer and to limiting doses of ovalbumin.分别定位与对谷氨酸-丙氨酸-酪氨酸共聚物和限量卵清蛋白的免疫反应相关的H-2连锁基因。
J Immunol. 1973 Dec;111(6):1621-5.
4
Genetic control of the immune response: the effect of non-H-2 linked genes on antibody production.免疫反应的遗传控制：非H-2连锁基因对抗体产生的影响。
J Immunol. 1974 Apr;112(4):1329-36.
5
Standardization of the chloramine-T method of protein iodination.蛋白质碘化氯胺-T法的标准化
Proc Soc Exp Biol Med. 1970 Mar;133(3):989-92. doi: 10.3181/00379727-133-34611.
6
Clonal nature of the immune response to phosphorylcholine. IV. Idiotypic uniformity of binding site-associated antigenic determinants among mouse antiphosphorylcholine antibodies.对磷酸胆碱免疫应答的克隆性质。IV. 小鼠抗磷酸胆碱抗体中与结合位点相关的抗原决定簇的独特型一致性。
J Exp Med. 1974 Sep 1;140(3):673-86. doi: 10.1084/jem.140.3.673.
7
Analysis of the cross-reactive immune suppression induced by the random copolymers L-glutamic acid50-L-tyrosine50 (GT), L-glutamic acid60-L-alanine40 and L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).对随机共聚物L-谷氨酸50-L-酪氨酸50（GT）、L-谷氨酸60-L-丙氨酸40和L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）诱导的交叉反应性免疫抑制的分析。
J Immunol. 1976 Nov;117(5 Pt 1):1603-7.
8
Human and murine phosphorycholine-binding immunoglobulins: conserved subgroup and first hypervariable region of heavy chains.人和小鼠磷酸胆碱结合免疫球蛋白：重链的保守亚群和第一个高变区
Proc Natl Acad Sci U S A. 1976 Jun;73(6):2096-100. doi: 10.1073/pnas.73.6.2096.
9
Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing.等电聚焦揭示的小鼠免疫球蛋白轻链的遗传多态性
J Exp Med. 1976 Jul 1;144(1):298-303. doi: 10.1084/jem.144.1.298.
10
Idiotypic analysis of anti-GAT antibodies. I. Presence of common idiotypic specificities in both responder and nonresponder mice.抗GAT抗体的独特型分析。I. 应答和非应答小鼠中共同独特型特异性的存在。
J Immunol. 1978 Sep;121(3):1034-9.

针对聚（Glu60Ala30Tyr10）抗体的独特型分析：品系间和种间独特型交叉反应

Idiotypic analysis of antibodies to poly(Glu60Ala30Tyr10): interstrain and interspecies idiotypic crossreactions.

作者信息

Ju S T, Benacerraf B, Dorf M E

出版信息

Proc Natl Acad Sci U S A. 1978 Dec;75(12):6192-6. doi: 10.1073/pnas.75.12.6192.

DOI:10.1073/pnas.75.12.6192
PMID:282636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC393145/
Abstract

A common idiotype was defined by a guinea pig anti-idiotypic antiserum made against D1.LP antibodies specific to the synthetic terpolymer poly(Glu60Ala30Tyr10), referred to as GAT. This idiotype was found in the anti-GAT antibodies of all individuals of all inbred strains of mice tested. Due to its common (C) occurrence in the anti-GAT antibodies of all mouse strains, it was termed the CGAT idiotype. The presence of CGAT idiotype in mice is independent of the expression of various Ig-1, H-2, or Vg genetic markers. In contrast, antibodies produced in response to the crossreactive poly(Glu60-Ala40), termed GA, bound to the GAT ligand but did not bear the CGAT idiotype. This suggests that GAT, although bearing GA determinants, preferentially stimulates clones of CGAT idiotype. Some of the CGAT idiotypic specificities were also identified in sera of WF inbred rats after immunization with GAT. However, no significant levels of CGAT idiotype were detected in LEW rats, F344 rats, guinea pigs, or rabbits, although measurable quantities of anti-GAT antibody were present.

摘要

一种常见独特型是由针对合成三元共聚物聚（Glu60Ala30Tyr10）（称为GAT）的D1.LP抗体产生的豚鼠抗独特型抗血清所定义。在所有测试的近交系小鼠个体的抗GAT抗体中都发现了这种独特型。由于其在所有小鼠品系的抗GAT抗体中普遍（C）存在，故将其称为CGAT独特型。小鼠中CGAT独特型的存在与各种Ig-1、H-2或Vg基因标记的表达无关。相反，针对交叉反应性聚（Glu60-Ala40）（称为GA）产生的抗体与GAT配体结合，但不具有CGAT独特型。这表明GAT虽然带有GA决定簇，但优先刺激CGAT独特型的克隆。在用GAT免疫后的WF近交系大鼠血清中也鉴定出了一些CGAT独特型特异性。然而，在LEW大鼠、F344大鼠、豚鼠或兔子中未检测到显著水平的CGAT独特型，尽管存在可测量量的抗GAT抗体。