Johnson C A, Cioffi G A, Van Buskirk E M
Devers Eye Institute, Discoveries in Sight Research Laboratory, Legacy Health Systems, Portland, Oregon 97210, USA.
Optom Vis Sci. 1999 Aug;76(8):571-81. doi: 10.1097/00006324-199908000-00026.
To assess whether smaller targets and a 24-2 stimulus presentation pattern would improve the ability of frequency doubling technology (FDT) perimetry to detect and characterize early glaucomatous visual field loss.
One hundred normal subjects between the ages of 20 and 85 participated in this study. In addition, 53 patients who either had early glaucomatous visual field loss (n = 23) or were high-risk glaucoma suspects with normal conventional visual fields (n = 30) were evaluated with the commercial version of FDT perimetry (full threshold test) with 17 stimuli (four 10 degrees diameter square targets per quadrant and a central 5 degrees circular target) and a custom version of FDT perimetry using 54 stimuli (4 degrees targets with 6 degrees grid spacing) arranged in a 24-2 stimulus presentation pattern.
The custom FDT test using a 24-2 stimulus presentation pattern had a similar dynamic range, and demonstrated normal aging characteristics and test-retest reliability that were similar to the commercial version of FDT perimetry using 17 larger stimuli. Both FDT tests showed an age-related sensitivity reduction of approximately 0.6 dB per decade, and exhibited an average test-retest reliability of 1 to 1.5 dB. The custom 24-2 FDT perimetry test had a greater variation of sensitivity with eccentricity than the commercial version of FDT perimetry that was probably related to the difference in stimulus size. The custom 24-2 FDT perimetry test had a greater percentage of abnormal test locations than the commercial FDT test for both early glaucomas and high-risk glaucoma suspects.
FDT perimetry can be performed with smaller targets using a presentation pattern that is similar to conventional automated perimetry. In comparison to the commercially available 17 target display, the 24-2 stimulus pattern appears to have modestly higher sensitivity for detection of early glaucomatous loss and provides better characterization of the pattern of visual field loss, but the test takes approximately twice as long.
评估较小的目标以及24-2刺激呈现模式是否会提高频率加倍技术（FDT）视野检查检测和描述早期青光眼性视野缺损的能力。
100名年龄在20至85岁之间的正常受试者参与了本研究。此外，对53例患者进行了评估，其中23例有早期青光眼性视野缺损，30例为常规视野正常的高风险青光眼疑似患者，使用商业版FDT视野检查（全阈值测试），有17个刺激（每个象限4个直径10度的方形目标和1个中心5度的圆形目标），以及使用定制版FDT视野检查，有54个刺激（4度目标，网格间距6度），以24-2刺激呈现模式排列。
使用24-2刺激呈现模式的定制FDT测试具有相似的动态范围，并显示出与使用17个较大刺激的商业版FDT视野检查相似的正常老化特征和重测信度。两种FDT测试均显示与年龄相关的敏感性每十年降低约0.6 dB，平均重测信度为1至1.5 dB。定制的24-2 FDT视野检查测试的敏感性随偏心率的变化比商业版FDT视野检查更大，这可能与刺激大小的差异有关。对于早期青光眼和高风险青光眼疑似患者，定制的24-2 FDT视野检查测试的异常测试位置百分比均高于商业FDT测试。
FDT视野检查可以使用与传统自动视野检查相似的呈现模式，采用较小的目标进行。与市售的17目标显示相比，24-2刺激模式在检测早期青光眼性视野缺损方面似乎具有略高的敏感性，并能更好地描述视野缺损模式，但该测试所需时间约为原来的两倍。
