Ayotte P, Dewailly E, Ryan J J, Bruneau S, Lebel G
Centre de Santé publique de Québec, CHUQ, Beauport, Canada.
Chemosphere. 1997 Mar-Apr;34(5-7):1459-68. doi: 10.1016/s0045-6535(97)00442-6.
Inuit people residing in the Arctic are unusually exposed to organochlorines through their traditional diet which includes large quantities of sea mammal fat. Recently, 499 Inuit adults from Nunavik (Arctic Quebec) participated in a large health survey and donated a blood sample for organochlorine and heavy metal analysis. Twenty pooled plasma samples were formed, each made of individual samples from the same age group, sex, and region of residence, to allow for dioxin-like compound determination. The mean total concentration of PCBs and dioxin-like compounds (the latter expressed in 2,3,7,8-TCDD toxic equivalents) were respectively 4.1 mg/kg lipids and 184.2 ng/kg lipids, compared to 0.13 mg/kg lipids and 26.1 ng/kg lipids for three control pooled plasma samples from Southern Quebec. Total PCBs and dioxin-like compound concentrations were strongly correlated (r = 0.98; p < 0.0001), increased with age and were greater in men than in women. Although the body burdens of PCBs and dioxin-like compounds are close to those which induced adverse health effects in laboratory animals, dietary benefits from the sea-food based diet still outweigh the hypothetical health risks.
居住在北极地区的因纽特人由于其传统饮食（包括大量海洋哺乳动物脂肪）而异常接触有机氯。最近，来自努纳维克（魁北克北极地区）的499名因纽特成年人参与了一项大型健康调查，并捐赠了血样用于有机氯和重金属分析。形成了20个混合血浆样本，每个样本由来自同一年龄组、性别和居住地区的个体样本组成，以便测定二恶英类化合物。多氯联苯和二恶英类化合物的平均总浓度（后者以2,3,7,8 - 四氯二苯并 - 对 - 二恶英毒性当量表示）分别为4.1毫克/千克脂质和184.2纳克/千克脂质，相比之下，来自魁北克南部的三个对照混合血浆样本样本的浓度分别为0.13毫克/千克脂质和26.1纳克/千克脂质。总多氯联苯和二恶英类化合物浓度高度相关（r = 0.98；p < 0.0001），随年龄增加，且男性高于女性。尽管多氯联苯和二恶英类化合物的体内负荷接近在实验动物中引起不良健康影响的水平，但基于海鲜的饮食带来的益处仍然超过假设的健康风险。
