Schouten M A, Voss A, Hoogkamp-Korstanje J A
University Hospital St. Radboud, Department of Medical Microbiology, 6500 HB Nijmegen, The Netherlands.
Antimicrob Agents Chemother. 1999 Oct;43(10):2542-6. doi: 10.1128/AAC.43.10.2542.
In vitro susceptibilities of 4,208 enterococci (83% Enterococcus faecalis isolates, 13.6% Enterococcus faecium isolates, and 3.4% isolates of other species) from patients in 27 European countries towards 16 antibiotics were determined. High-level resistance to gentamicin varied by country (range, 1 to 49%; mean, 22.6% +/- 12. 3%) and per species (19.7% E. faecalis isolates, 13.6% E. faecium isolates, 3.4% by other species). Vancomycin resistance was detected in 0.06% E. faecalis, 3.8% E. faecium, and 19.1% isolates of other species. All enterococci were susceptible to LY 333328 and everninomicin, and 25% of E. faecalis isolates and 85% of other enterococci were susceptible to quinupristin-dalfopristin. The MIC of moxifloxacin and trovafloxacin for ciprofloxacin-susceptible E. faecalis at which 90% of the isolates were inhibited was 0.25 to 0.5 microg/ml.
对来自27个欧洲国家患者的4208株肠球菌（83%为粪肠球菌分离株，13.6%为屎肠球菌分离株，3.4%为其他菌种的分离株）进行了16种抗生素的体外药敏试验。对庆大霉素的高水平耐药性因国家而异（范围为1%至49%；平均为22.6%±12.3%），且因菌种不同而有所差异（粪肠球菌分离株中为19.7%，屎肠球菌分离株中为13.6%，其他菌种中为3.4%）。在粪肠球菌中检测到0.06%的万古霉素耐药，屎肠球菌中为3.8%，其他菌种中为19.1%。所有肠球菌对LY 333328和埃维霉素敏感，25%的粪肠球菌分离株和85%的其他肠球菌对奎奴普丁-达福普汀敏感。对环丙沙星敏感的粪肠球菌，90%的分离株被抑制时，莫西沙星和曲伐沙星的MIC为0.25至0.5微克/毫升。
