来自马岛香材树的两种6-取代的5,6-二氢-α-吡喃酮。

Two 6-substituted 5,6-dihydro-alpha-pyrones from Ravensara anisata.

作者信息

Andrianaivoravelona J O, Sahpaz S, Terreaux C, Hostettmann K, Stoeckli-Evans H, Rasolondramanitra J

机构信息

Centre National de Recherches Industrielles et Technologiques, Antananarivo, Madagascar.

出版信息

Phytochemistry. 1999 Sep;52(2):265-9. doi: 10.1016/s0031-9422(99)00158-2.

DOI:10.1016/s0031-9422(99)00158-2

PMID:10513401

Abstract

The leaves and bark dichloromethane extracts of Ravensara anisata showed antifungal activity against the yeast Candida albicans and the phytopathogenic fungus Cladosporium cucumerinum in bioautographic TLC assays. Activity-guided fractionation afforded two new alpha-pyrones: 6R*-(4R*-acetoxy-2S*-hydroxy- 8-phenyloctyl)-5,6-dihydro-2-H-pyran-2-one and 6R*-(2S*-acetoxy-4R*- hydroxy-8-phenyloctyl)-5,6-dihydro-2-H-pyran-2-one. Their structures have been established by NMR spectroscopy, chemical methods and X-ray crystallographic analysis. The antifungal activity against C. albicans and C. cucumerinum was determined for both compounds.

摘要

在生物自显影薄层色谱分析中，马岛香树的叶和树皮二氯甲烷提取物对白色念珠菌和植物病原真菌黄瓜枝孢菌显示出抗真菌活性。活性导向分离得到了两个新的α-吡喃酮：6R*-(4R*-乙酰氧基-2S*-羟基-8-苯基辛基)-5,6-二氢-2H-吡喃-2-酮和6R*-(2S*-乙酰氧基-4R*-羟基-8-苯基辛基)-5,6-二氢-2H-吡喃-2-酮。它们的结构已通过核磁共振光谱、化学方法和X射线晶体学分析确定。测定了这两种化合物对白色念珠菌和黄瓜枝孢菌的抗真菌活性。