龙舌兰科龙血树新鲜茎中的甾体皂苷。
Steroidal saponins from fresh stems of Dracaena angustifolia.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, People's Republic of China.
出版信息
J Nat Prod. 2010 Sep 24;73(9):1524-8. doi: 10.1021/np100351p.
Abstract
Six new steroidal saponins (1-6), angudracanosides A-F, were isolated from fresh stems of Dracaena angustifolia, together with eight known compounds. The structures of compounds 1-6 were determined by detailed spectroscopic analyses and chemical methods. Antifungal testing of all compounds showed that 6 and 7 were active against Cryptococcus neoformans with IC(50)s of 9.5 and 20.0 μg/mL, respectively.
摘要
从龙血树新鲜茎中分离得到 6 个新甾体皂苷（1-6），分别为 angudracanosides A-F，以及 8 个已知化合物。通过详细的光谱分析和化学方法确定了化合物 1-6 的结构。所有化合物的抗真菌测试表明，化合物 6 和 7 对新型隐球菌具有活性，IC50 分别为 9.5 和 20.0 μg/mL。
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2
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3
Dracaenogenins A and B, new spirostanols from the red resin of Dracaena cochinchinensis.
Steroids. 2006 Feb;71(2):160-4. doi: 10.1016/j.steroids.2005.09.007. Epub 2005 Nov 2.
4
Biological activities and distribution of plant saponins.
J Ethnopharmacol. 2004 Oct;94(2-3):219-43. doi: 10.1016/j.jep.2004.05.016.
5
[Studies on the chemical constituents from Tribulus terrestris].
Yao Xue Xue Bao. 2001 Oct;36(10):750-3.
6
A new bioactive steroidal saponin from Agave attenuata.
Z Naturforsch C J Biosci. 2002 May-Jun;57(5-6):423-8. doi: 10.1515/znc-2002-5-603.
7
New spirostanol steroids and steroidal saponins from roots and rhizomes of Dracaena angustifolia and their antiproliferative activity.
J Nat Prod. 2001 Sep;64(9):1127-32. doi: 10.1021/np0100385.
8
Two 6-substituted 5,6-dihydro-alpha-pyrones from Ravensara anisata.
Phytochemistry. 1999 Sep;52(2):265-9. doi: 10.1016/s0031-9422(99)00158-2.
9
Two auronols from Pseudolarix amabilis.
J Nat Prod. 1999 May;62(5):767-9. doi: 10.1021/np980469w.
10
Steroidal saponins from the leaves of Cordyline stricta.
Phytochemistry. 1998 Jan;47(1):79-85. doi: 10.1016/s0031-9422(97)00545-1.
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