Matsumoto M, Minami T, Sasaki H, Sobue S, Hamada S, Ooshima T
Department of Pedodontics, Faculty of Dentistry, Osaka University, Suita, Osaka, Japan.
Caries Res. 1999 Nov-Dec;33(6):441-5. doi: 10.1159/000016549.
The inhibitory effects of oolong tea extract (OTE) on the caries-inducing properties of mutans streptococci were examined in vitro. OTE reduced the rate of acid production by mutans streptococci accompanied with the retardation of growth rate of mutans streptococci, while the action by chromatographically isolated oolong tea polyphenol (OTF6) was weak. On the other hand, both oolong tea products decreased cell surface hydrophobicity of almost all the oral streptococci examined in the present study, and also induced cellular aggregation of Streptococcus mutans, Streptococcus oralis, Streptococcus sanguis or Streptococcus gordonii. In these reactions, OTF6 showed a more pronounced activity than OTE. Furthermore, the oolong tea products inhibited the adherence of mutans streptococci to saliva-coated hydroxyapatite. These results suggest that OTF6 may inhibit bacterial adherence to the tooth surfaces by reducing the hydrophobicity of mutans streptococci, and OTE may inhibit caries-inducing activity of mutans streptococci by reducing the rate of acid production.
体外研究了乌龙茶提取物（OTE）对变形链球菌致龋特性的抑制作用。OTE降低了变形链球菌的产酸速率，同时减缓了变形链球菌的生长速度，而经色谱分离的乌龙茶多酚（OTF6）的作用较弱。另一方面，两种乌龙茶产品均降低了本研究中几乎所有检测的口腔链球菌的细胞表面疏水性，还诱导了变形链球菌、口腔链球菌、血链球菌或戈登链球菌的细胞聚集。在这些反应中，OTF6比OTE表现出更显著的活性。此外，乌龙茶产品抑制了变形链球菌对唾液包被的羟基磷灰石的黏附。这些结果表明，OTF6可能通过降低变形链球菌的疏水性来抑制细菌对牙齿表面的黏附，而OTE可能通过降低产酸速率来抑制变形链球菌的致龋活性。
