Saeki Y, Kato T, Naito Y, Takazoe I, Okuda K
Department of Bio-Technology, Lotte Central Laboratory Co., Ltd., Saitama, Japan.
Caries Res. 1996;30(2):119-25. doi: 10.1159/000262147.
Funoran, a sulfated polysaccharide extracted from the seaweed Gloiopeltis furcata strongly inhibited the absorption of mutans streptococci to saliva-coated hydroxyapatite (S-HA), but enhanced that of Streptococcus sanguis ATCC 10556 and Streptococcus oralis ATCC 10557. Furthermore, funoran had a strong desorption activity against mutans streptococci preadsorbed to S-HA. In the presence of sucrose, the absorption of cells of Streptococcus sobrinus B13, Streptococcus mutans Ingbritt, and S. mutans MT8148R to S-HA was strongly inhibited by 0.01% funoran. The colonization of S. sobrinus 6715 inoculated on the molar teeth of experimental rats that were administered funoran was less frequent than that in a funoran-free group. The mean buccal and lingual, sulcal, and total caries scores of rat groups administered funoran were significantly lower than those of the funoran-free group.
岩藻聚糖是一种从海草叉枝藻中提取的硫酸化多糖，它能强烈抑制变形链球菌对唾液包被的羟基磷灰石（S-HA）的吸附，但能增强血链球菌ATCC 10556和口腔链球菌ATCC 10557对其的吸附。此外，岩藻聚糖对预先吸附在S-HA上的变形链球菌具有很强的解吸活性。在蔗糖存在的情况下，0.01%的岩藻聚糖能强烈抑制远缘链球菌B13、变形链球菌Ingbritt和变形链球菌MT8148R细胞对S-HA的吸附。给实验大鼠的磨牙接种远缘链球菌6715后，给予岩藻聚糖的大鼠组中该菌的定植频率低于未给予岩藻聚糖的组。给予岩藻聚糖的大鼠组的颊面、舌面、龈沟和总龋均得分显著低于未给予岩藻聚糖的组。
