乙酰胆碱受体与胸腺之间的免疫学关系：对重症肌无力可能具有的意义。
Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.
作者信息
Aharonov A, Tarrab-Hazdai R, Abramsky O, Fuchs S
出版信息
Proc Natl Acad Sci U S A. 1975 Apr;72(4):1456-9. doi: 10.1073/pnas.72.4.1456.
Abstract
A defined immunological cross-reaction was observed between acetylcholine receptor fraction from the electric eel, Electrophorus electricus, and two calf thymus fractions. The cross-reaction was demonstrated on the cellular level by means of the lymphocyte transformation technique, and on the humoral level, by means of the microcomplement fixation assay. In the human disease myasthenia gravis both acetylcholine receptor at the neuromuscular junction and the thymus are affected, probably by an autoimmune mechanism. The immunological cross-reaction between acetylcholine receptor and thymic components may explain the association between endplate and thymus disorders in myasthenia gravis.
摘要
在电鳗（Electrophorus electricus）的乙酰胆碱受体组分与小牛胸腺的两种组分之间观察到了明确的免疫交叉反应。通过淋巴细胞转化技术在细胞水平上证实了这种交叉反应，在体液水平上则通过微量补体结合试验得到了证实。在人类疾病重症肌无力中，神经肌肉接头处的乙酰胆碱受体和胸腺均受到影响，可能是通过自身免疫机制。乙酰胆碱受体与胸腺成分之间的免疫交叉反应可能解释了重症肌无力终板和胸腺疾病之间的关联。
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