近交系豚鼠中淋巴结细胞对实验性自身免疫性重症肌无力的被动转移
Passive transfer of experimental autoimmune myasthenia by lymph node cells in inbred guinea pigs.
作者信息
Tarrab-Hazdi R, Aharonov A, Abramsky O, Yaar I, Fuchs S
出版信息
J Exp Med. 1975 Sep 1;142(3):785-9. doi: 10.1084/jem.142.3.785.
Abstract
Passive transfer of experimental autoimmune myasthenia (EAM) was performed with lymph node cells from donor guinea pigs immunized with purified acetylcholine receptor (AChR) from Torpedo californica. Recipient animals revealed the same clinical signs and electromyographic patterns as observed in actively challenged animals. These phenomena are parallel to the clinical manifestations of the human disease myasthenia gravis, in which cellular response to AChR was recently demonstrated.
摘要
用来自用加利福尼亚电鳐纯化的乙酰胆碱受体（AChR）免疫的供体豚鼠的淋巴结细胞进行实验性自身免疫性重症肌无力（EAM）的被动转移。受体动物表现出与主动攻击动物中观察到的相同临床症状和肌电图模式。这些现象与人类疾病重症肌无力的临床表现相似，最近已证实重症肌无力中存在对AChR的细胞反应。
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本文引用的文献
1
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Adv Immunol. 1966;5:131-208. doi: 10.1016/s0065-2776(08)60273-4.
2
Autoimmune response to acetylcholine receptor.对乙酰胆碱受体的自身免疫反应。
Science. 1973 May 25;180(4088):871-2. doi: 10.1126/science.180.4088.871.
3
Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis.
Neurology. 1974 Jun;24(6):560-4. doi: 10.1212/wnl.24.6.560.
4
Cellular immune response to acetylcholine receptor-rich fraction, in patients with myasthenia gravis.重症肌无力患者对富含乙酰胆碱受体组分的细胞免疫反应。
Clin Exp Immunol. 1975 Jan;19(1):11-6.
5
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