Stanghellini V
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy.
Scand J Gastroenterol Suppl. 1999;231:20-8. doi: 10.1080/003655299750025237.
This paper reports the 3-month prevalence rates of gastrointestinal (GI) symptoms from the Domestic/International Gastroenterology Surveillance Study (DIGEST), and their relationship with demographic factors; namely age, gender and body mass index (BMI).
Subjects were recruited from 10 international sites by a total of 5581 face-to-face interviews conducted with randomly selected members of the general population aged 18 years and over (50.6% female; mean age 44 years). The sample was divided according to whether subjects reported 1 or more of 14 GI symptoms, or no GI symptoms. Those with any of 11 upper GI symptoms were then subdivided according to their most bothersome symptom: gastro-oesophageal reflux (GORD)-like symptoms, ulcer-like symptoms or dysmotility-like symptoms. Symptoms were classified as relevant if they were of at least moderate severity and/or occurred at least once a week.
A mean of 46.4% of subjects reported experiencing one or more of the 14 GI symptoms, with 28.1% experiencing upper GI symptoms classified as relevant. Significant differences between the prevalences of relevant symptoms were evident between sampling sites. The estimated prevalence of GORD-like symptoms for the pooled sample was 7.7%. For ulcer-like symptoms, prevalence was 4.1%, and for dysmotility-like symptoms 15.5%. Significant differences were observed in the prevalence rates of symptom groups between countries. Women were significantly more likely than men to experience relevant symptoms, with gender differences also observed in the rates of GORD-like and dysmotility-like symptoms. The proportion of those with relevant symptoms experiencing GORD-like symptoms increased significantly with age; ulcer-like symptoms showed no significant relationship with age; and dysmotility-like symptoms decreased significantly with age. The prevalence of relevant symptoms increased with increasing BMI.
In conclusion, the DIGEST has provided valuable data on the cross-country prevalence of upper GI symptoms, and their association with biological factors.
本文报告了国内/国际胃肠病学监测研究（DIGEST）中胃肠道（GI）症状的3个月患病率，以及它们与人口统计学因素（即年龄、性别和体重指数（BMI））的关系。
通过对18岁及以上普通人群的随机抽样成员进行5581次面对面访谈，从10个国际地点招募受试者（女性占50.6%；平均年龄44岁）。根据受试者是否报告14种胃肠道症状中的1种或更多种，或未报告任何胃肠道症状，将样本进行划分。然后，将有11种上消化道症状中的任何一种的受试者，根据其最困扰的症状进一步细分：胃食管反流（GORD）样症状、溃疡样症状或动力障碍样症状。如果症状至少为中度严重程度和/或每周至少出现一次，则分类为相关症状。
平均46.4%的受试者报告经历了14种胃肠道症状中的1种或更多种，28.1%的受试者经历了分类为相关的上消化道症状。各抽样地点相关症状的患病率之间存在显著差异。汇总样本中GORD样症状的估计患病率为7.7%。溃疡样症状的患病率为4.1%，动力障碍样症状的患病率为15.5%。不同国家症状组的患病率存在显著差异。女性比男性更有可能经历相关症状，在GORD样症状和动力障碍样症状的发生率上也观察到性别差异。有相关症状且经历GORD样症状的比例随年龄显著增加；溃疡样症状与年龄无显著关系；动力障碍样症状随年龄显著降低。相关症状患病率随BMI增加而升高。
总之，DIGEST提供了关于上消化道症状的跨国患病率及其与生物学因素关联的宝贵数据。
