Choi Y K, Simon M A, Kim D Y, Yoon B I, Kwon S W, Lee K W, Seo I B, Kim D Y
Korea Research Institute of Bioscience and Biotechnology, Taejon.
Vet Pathol. 1999 Nov;36(6):594-600. doi: 10.1354/vp.36-6-594.
An outbreak of natural measles virus infection occurred in a group of Japanese macaques (Macaca fuscata). Over a period of 4 months, 12 of 53 Japanese macaques died following a 2-23-day history of anorexia, diarrhea, and dermatitis. The monkeys were kept in outdoor exhibits but had been moved temporarily into indoor caging and then transferred to new outdoor exhibits. Ten monkeys died while they were in temporary caging, and two monkeys died after they were moved to new outdoor exhibits. The diagnoses were made based on the results of histopathology, immunohistochemistry (IHC), in situ hybridization (ISH), and electron microscopy. Measles virus antigens were detected in the lung, stomach, skin, salivary gland, spleen, and lymph nodes. Tangled, tubular nucleocapsids compatible with paramyxovirus were noted in the lung tissue. As a result of immunosuppression following measles virus infection, various secondary infections including disseminated cytomegalovirus infection, adenoviral and bacterial pneumonia, and Candida albicans-associated gingivitis and esophagitis were noted. The primary infective source or the mode of infection could not be determined in this outbreak, but measles virus may have been transmitted to the monkeys from human visitors while the monkeys were on exhibit.
一群日本猕猴（猕猴属）中发生了自然麻疹病毒感染疫情。在4个月的时间里，53只日本猕猴中有12只在出现2至23天的厌食、腹泻和皮炎症状后死亡。这些猴子饲养在室外展区，但曾被临时转移到室内笼子里，然后又被转移到新的室外展区。10只猴子在临时关在笼子里时死亡，2只猴子在被转移到新的室外展区后死亡。诊断是根据组织病理学、免疫组织化学（IHC）、原位杂交（ISH）和电子显微镜检查结果做出的。在肺、胃、皮肤、唾液腺、脾脏和淋巴结中检测到麻疹病毒抗原。在肺组织中发现了与副粘病毒相符的缠结管状核衣壳。由于麻疹病毒感染后的免疫抑制，出现了各种继发感染，包括播散性巨细胞病毒感染、腺病毒和细菌性肺炎以及白色念珠菌相关的牙龈炎和食管炎。此次疫情中无法确定主要传染源或感染方式，但麻疹病毒可能是在猴子展出期间从人类参观者传播给它们的。
