Lukashov V V, Huismans R, Rakhmanova A G, Lisitsina Z N, Akhtyrskaya N A, Vlasov N N, Melnick O B, Goudsmit J
Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands.
AIDS Res Hum Retroviruses. 1999 Nov 20;15(17):1577-83. doi: 10.1089/088922299309874.
Countries of the former Soviet Union are experiencing an emerging HIV-1 epidemic due to a rapid expansion of HIV-1 among injecting drug users (IDUs). To study the molecular epidemiology of HIV-1 among IDUs in St. Petersburg, Russia, virus sequences were obtained from 22 individuals. Phylogenetic analysis of the env and gag regions revealed circulation of two major HIV-1 populations, one belonging to HIV-1 subtype A, and another being a recombinant of subtype A and B viruses (gagA/envB). Both virus populations were highly homogeneous, with a mean pairwise genetic distance of <2%, and similar to viruses obtained earlier from IDUs in other regions of the former Soviet Union. Distribution of the two major HIV-1 genotypes in St. Petersburg correlated with geographical origin of infections. In one individual, a virus type previously unseen among IDUs was found, which demonstrates the possibility that new viruses are entering this risk group.
由于艾滋病毒-1在注射吸毒者中迅速传播，前苏联国家正经历着一场新出现的艾滋病毒-1疫情。为了研究俄罗斯圣彼得堡注射吸毒者中艾滋病毒-1的分子流行病学，从22名个体中获取了病毒序列。对env和gag区域的系统发育分析揭示了两种主要艾滋病毒-1群体的传播情况，一种属于艾滋病毒-1 A亚型，另一种是A亚型和B亚型病毒的重组体（gagA/envB）。两种病毒群体高度同源，平均成对遗传距离<2%，并且与先前从前苏联其他地区的注射吸毒者中获得的病毒相似。圣彼得堡两种主要艾滋病毒-1基因型的分布与感染的地理来源相关。在一名个体中，发现了一种以前在注射吸毒者中未见过的病毒类型，这表明新病毒有可能正在进入这个风险群体。
