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Appl Environ Microbiol. 1999 Dec;65(12):5639-41. doi: 10.1128/AEM.65.12.5639-5641.1999.
2
The affinity purification and characterization of a dehydrogenase from Aspergillus parasiticus involved in aflatoxin B1 biosynthesis.寄生曲霉中参与黄曲霉毒素B1生物合成的一种脱氢酶的亲和纯化及特性分析。
Prep Biochem. 1991;21(2-3):125-40. doi: 10.1080/10826069108018008.
3
The preparation of an enzyme associated with aflatoxin biosynthesis by affinity chromatography.通过亲和色谱法制备与黄曲霉毒素生物合成相关的酶。
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Molecular characterization of an Aspergillus parasiticus dehydrogenase gene, norA, located on the aflatoxin biosynthesis gene cluster.位于黄曲霉毒素生物合成基因簇上的寄生曲霉脱氢酶基因norA的分子特征分析。
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本文引用的文献

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Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus.寄生曲霉黄曲霉毒素生物合成相关的nor-1基因的结构与功能分析
Appl Environ Microbiol. 1994 Nov;60(11):4078-85. doi: 10.1128/aem.60.11.4078-4085.1994.
2
Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway.鉴定averantin为黄曲霉毒素B1前体：确定其在生物合成途径中的位置。
Appl Environ Microbiol. 1980 Apr;39(4):835-9. doi: 10.1128/aem.39.4.835-839.1980.
3
Studies in mycological chemistry. XIX. "Product B" (averantin) [1,3,6,8-tetrahydroxy-2-(1-hydroxyhexyl)anthraquinone], a pigment from Aspergillus versicolor (Vuillemin) Tiraboschi.真菌化学研究。十九。“产物B”（阿弗菌素）[1,3,6,8 - 四羟基 - 2 -（1 - 羟基己基）蒽醌]，一种来自杂色曲霉（蒂拉博斯基）的色素。
J Chem Soc Perkin 1. 1966;9:855-7. doi: 10.1039/j39660000855.
4
Norsolorinic acid from a mutant strain of Aspergillus parasiticus.来自寄生曲霉突变株的降红青霉素酸。
J Am Oil Chem Soc. 1971 Feb;48(2):93-4. doi: 10.1007/BF02635696.
5
Isolation of averufin from a mutant of Aspergillus parasiticus impaired in aflatoxin biosynthesis.从黄曲霉毒素生物合成受损的寄生曲霉突变体中分离出黄绿青霉素。
Biochem Biophys Res Commun. 1972 Jun 9;47(5):1051-5. doi: 10.1016/0006-291x(72)90939-4.
6
Enzymes and aflatoxin biosynthesis.酶与黄曲霉毒素生物合成
Microbiol Rev. 1988 Jun;52(2):274-95. doi: 10.1128/mr.52.2.274-295.1988.
7
Enzymatic conversion of norsolorinic acid to averufin in aflatoxin biosynthesis.黄曲霉毒素生物合成中诺索尔紫红质酸向奥佛尼菌素的酶促转化。
Appl Environ Microbiol. 1991 May;57(5):1340-5. doi: 10.1128/aem.57.5.1340-1345.1991.
8
The affinity purification and characterization of a dehydrogenase from Aspergillus parasiticus involved in aflatoxin B1 biosynthesis.寄生曲霉中参与黄曲霉毒素B1生物合成的一种脱氢酶的亲和纯化及特性分析。
Prep Biochem. 1991;21(2-3):125-40. doi: 10.1080/10826069108018008.
9
Cloning of a gene associated with aflatoxin B1 biosynthesis in Aspergillus parasiticus.寄生曲霉中与黄曲霉毒素B1生物合成相关基因的克隆
Curr Genet. 1992 Mar;21(3):231-3. doi: 10.1007/BF00336846.

寄生曲霉中nor-1蛋白在黄曲霉毒素生物合成中的酶功能。

Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.

作者信息

Zhou R, Linz J E

机构信息

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824-1224, USA.

出版信息

Appl Environ Microbiol. 1999 Dec;65(12):5639-41. doi: 10.1128/AEM.65.12.5639-5641.1999.

DOI:10.1128/AEM.65.12.5639-5641.1999
PMID:10584035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC91775/
Abstract

The nor-1 gene is involved in aflatoxin biosynthesis in Aspergillus parasiticus and was predicted to encode a norsolorinic acid ketoreductase. Recombinant Nor-1 expressed in Escherichia coli converted the 1' keto group of norsolorinic acid to the 1' hydroxyl group of averantin in crude E. coli cell extracts in the presence of NADPH. The results confirm that Nor-1 functions as a ketoreductase in vitro.

摘要

nor-1基因参与寄生曲霉中黄曲霉毒素的生物合成，据预测它编码一种诺索洛林酸酮还原酶。在大肠杆菌中表达的重组Nor-1在NADPH存在的情况下，能将大肠杆菌粗细胞提取物中的诺索洛林酸的1'酮基转化为阿弗菌素的1'羟基。结果证实Nor-1在体外起酮还原酶的作用。