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1
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Proc Natl Acad Sci U S A. 1975 Aug;72(8):3255-9. doi: 10.1073/pnas.72.8.3255.
2
Hormonal regulation of ovarian ecdysteroid production in the autogenous mosquito, Aedes atropalpus.自育型蚊虫阿氏伊蚊卵巢蜕皮甾体生成的激素调节
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3
Multiple forms of cerebral peptides with steroidogenic functions in pupal and adult brains of the yellow fever mosquito, Aedes aegypti.在黄热病蚊子埃及伊蚊的蛹脑和成虫脑中具有类固醇生成功能的多种脑肽形式。
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Ecdysone-mediated stimulation of DOPA decarboxylase activity and its relationship to ovarian development in Aedes aegypti.蜕皮激素介导的埃及伊蚊多巴脱羧酶活性刺激及其与卵巢发育的关系。
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6
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本文引用的文献

1
Arthropod molting hormone: radioimmune assay.节肢动物蜕皮激素：放射免疫测定。
Science. 1972 Oct 27;178(4059):418-9. doi: 10.1126/science.178.4059.418.
2
Vitellogenic blood protein synthesis by insect fat body.昆虫脂肪体的卵黄原蛋白合成
Science. 1969 Jul 25;165(3891):393-4. doi: 10.1126/science.165.3891.393.
3
Biosynthesis of agr-Ecdysone by Prothoracic Glands in vitro.前胸腺体外生物合成蜕皮激素 agr-Ecdysone。
Science. 1974 Feb 8;183(4124):529-30. doi: 10.1126/science.183.4124.529.
4
The Secretion of alpha-Ecdysone by the Prothoracic Glands of Manduca sexta In Vitro.烟草天蛾前胸腺体外分泌α-蜕皮激素
Proc Natl Acad Sci U S A. 1974 Mar;71(3):793-6. doi: 10.1073/pnas.71.3.793.
5
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
6
A simple colorimetric method for determination of protein.一种测定蛋白质的简单比色法。
Anal Biochem. 1969 Oct 1;31(1):146-8. doi: 10.1016/0003-2697(69)90251-6.
7
Hormonal control of ovarian development and metamorphosis in Malacosoma pluviale.雨毒蛾卵巢发育和变态的激素控制
Can J Zool. 1969 Sep;47(5):917-20. doi: 10.1139/z69-149.
8
Induction of puffs in polytene chromosomes of in vitro cultured salivary glands of Drosophila melanogaster by ecdysone and echysone analogues.蜕皮激素和蜕皮激素类似物对体外培养的黑腹果蝇唾液腺多线染色体中膨泡的诱导作用。
Nat New Biol. 1971 Apr 14;230(15):222-4. doi: 10.1038/newbio230222a0.
9
Hormonal conditions necessary for evolution of the ovary in the pupa of Tenebrio molitor (Coleoptera).黄粉虫（鞘翅目）蛹期卵巢发育所需的激素条件。
Gen Comp Endocrinol. 1971 Dec;17(3):467-78. doi: 10.1016/0016-6480(71)90181-x.
10
Ecdysone-mediated stimulation of DOPA decarboxylase activity and its relationship to ovarian development in Aedes aegypti.蜕皮激素介导的埃及伊蚊多巴脱羧酶活性刺激及其与卵巢发育的关系。
J Cell Biol. 1974 May;61(2):454-65. doi: 10.1083/jcb.61.2.454.

成年蚊子体内作为α-蜕皮激素来源的卵巢。

The ovary as a source of alpha-ecdysone in an adult mosquito.

作者信息

Hagedorn H H, O'Connor J D, Fuchs M S, Sage B, Schlaeger D A, Bohm M K

出版信息

Proc Natl Acad Sci U S A. 1975 Aug;72(8):3255-9. doi: 10.1073/pnas.72.8.3255.

DOI:10.1073/pnas.72.8.3255
PMID:1059110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432961/
Abstract

The ovaries of the mosquito Aedes aegypti cultured in vitro secrete material that behaves like ecdysone in a radioimmunoassay. The material was identified as alpha-ecdysone by high-resolution liquid and gas-liquid chromatography. Secretion reached a maximum 16 hr after a blood meal as shown by bioassay and direct determination. Ovariectomy reduced the concentration of ecdysone in the adult after a blood meal. Qualitative analysis of whole-body extracts indicated beta-ecdysone to be the principal species present. Thus the ovaries appear to secrete a prohormone, alpha-ecdysone, which is converted to beta-ecdysone. Beta-ecdysone plays a significant role in stimulating egg development in the adult mosquito and may have reproductive roles in other insects.

摘要

在体外培养的埃及伊蚊卵巢分泌的物质，在放射免疫分析中表现得像蜕皮激素。通过高分辨率液相色谱和气相色谱法，该物质被鉴定为α-蜕皮激素。生物测定和直接测定表明，吸血后16小时分泌量达到最大值。卵巢切除降低了吸血后成虫体内蜕皮激素的浓度。对全身提取物的定性分析表明，β-蜕皮激素是主要存在的种类。因此，卵巢似乎分泌一种前体激素α-蜕皮激素，它会转化为β-蜕皮激素。β-蜕皮激素在刺激成年蚊子卵子发育中起重要作用，并且可能在其他昆虫中具有生殖作用。