Schulze B, Wubbolts M G
DSM Research, PO Box 18, Geleen, 6160 MD, The Netherlands. birgit.
Curr Opin Biotechnol. 1999 Dec;10(6):609-15. doi: 10.1016/s0958-1669(99)00042-7.
Chiral intermediates constitute a significant part of the fine chemicals market, which is strongly influenced by trends in the pharmaceutical industries, where approximately 70% of pharmaceuticals are expected to be enantiomerically pure in the next century as compared to 25% today. The main technologies by which enantiomerically pure ingredients are obtained today are (dynamic) resolutions of racemic mixtures. Asymmetric syntheses are being developed, but their applications in industry are still under represented. Biotechnological methods, resolutions as well as asymmetric syntheses, are becoming increasingly important in the industrial production of fine chemicals.
手性中间体在精细化学品市场中占据重要份额，该市场受到制药行业趋势的强烈影响。预计在下个世纪，约70%的药品将是对映体纯的，而如今这一比例为25%。目前获得对映体纯成分的主要技术是（动态）拆分外消旋混合物。不对称合成正在发展，但它们在工业中的应用仍未得到充分体现。生物技术方法，包括拆分以及不对称合成，在精细化学品的工业生产中变得越来越重要。
