Mendelsohn A L, Dreyer B P, Fierman A H, Rosen C M, Legano L A, Kruger H A, Lim S W, Barasch S, Au L, Courtlandt C D
Department of Pediatrics, New York University School of Medicine and Bellevue Hospital Center, NY 10016, USA.
J Dev Behav Pediatr. 1999 Dec;20(6):425-31. doi: 10.1097/00004703-199912000-00004.
The authors studied toddlers with low-level lead exposure to determine whether adverse developmental effects were evident. The study sample consisted of a cohort of 68 children aged 12 to 36 months who had blood lead levels lower than 25 microg/dL on a routine screening in a large urban public hospital clinic. Children with blood lead levels between 10 and 24.9 microg/dL had a mean Mental Developmental Index (Bayley Scales of Infant Development, Second Edition) score that was 6.3 points lower than that of children with blood lead levels between 0 and 9.9 microg/dL (95% confidence interval: 0.6, 11.9). After adjusting for confounders, the difference was 6.2 points (95% confidence interval: 1.7, 10.8). Pediatricians and public health entities should continue in their efforts to reduce the lead burden through environmental control and ongoing surveillance.
作者对低水平铅暴露的幼儿进行了研究，以确定是否存在明显的不良发育影响。研究样本包括一组68名年龄在12至36个月之间的儿童，他们在一家大型城市公立医院诊所的常规筛查中血铅水平低于25微克/分升。血铅水平在10至24.9微克/分升之间的儿童，其平均心理发育指数（贝利婴儿发育量表，第二版）得分比血铅水平在0至9.9微克/分升之间的儿童低6.3分（95%置信区间：0.6，11.9）。在对混杂因素进行调整后，差异为6.2分（95%置信区间：1.7，10.8）。儿科医生和公共卫生机构应继续努力，通过环境控制和持续监测来减轻铅负担。
