Tsubokawa N, Maki Y, Yoshizu T, Narisawa H
Niigata Hand Surgery Foundation, Japan.
Scand J Plast Reconstr Surg Hand Surg. 1999 Dec;33(4):379-85. doi: 10.1080/02844319950159073.
We examined the inductive ability of motor and sensory Schwann cells on regeneration of motor and sensory axons using a silastic Y chamber, and Lewis rats L5 ventral root (motor) and saphenous nerve (sensory). We developed four experimental models: motor-motor nerve group-proximal motor stump with distal fresh and frozen/thawed motor nerve segments (n = 7); sensory-sensory nerve group-proximal sensory stump with distal fresh and frozen/thawed sensory nerve segments (n = 7); motor-sensory nerve group-proximal motor stump with distal fresh and frozen/thawed sensory segments (n = 8); and sensory-motor nerve group-proximal sensory stump with distal fresh and frozen/thawed motor segments (n = 8). The gap was set at 4 mm. Six weeks postoperatively we compared the number of regenerated myelinated axons in the two distal channels, and found that sensory Schwann cells have a strong inductive ability for regeneration of both sensory and motor axons. Motor Schwann cells have weak inductive ability for regeneration of motor axons and no inductive ability for regeneration of sensory axons.
我们使用硅橡胶Y形腔室以及Lewis大鼠的L5腹根（运动神经）和隐神经（感觉神经），研究了运动性和感觉性雪旺细胞对运动和感觉轴突再生的诱导能力。我们建立了四种实验模型：运动-运动神经组——近端运动神经残端与远端新鲜及冷冻/解冻的运动神经段相连（n = 7）；感觉-感觉神经组——近端感觉神经残端与远端新鲜及冷冻/解冻的感觉神经段相连（n = 7）；运动-感觉神经组——近端运动神经残端与远端新鲜及冷冻/解冻的感觉神经段相连（n = 8）；以及感觉-运动神经组——近端感觉神经残端与远端新鲜及冷冻/解冻的运动神经段相连（n = 8）。间隙设定为4毫米。术后六周，我们比较了两个远端通道中再生有髓轴突的数量，发现感觉性雪旺细胞对感觉和运动轴突的再生均具有较强的诱导能力。运动性雪旺细胞对运动轴突再生的诱导能力较弱，对感觉轴突再生则无诱导能力。
