Maki Yutaka, Yoshizu Takae, Tsubokawa Naoto
Niigata Hand Surgery Foundation, Niigata, Japan.
Scand J Plast Reconstr Surg Hand Surg. 2005;39(5):257-60. doi: 10.1080/0284431051006510.
We assessed the selectivity of motor and sensory axon regeneration towards the distal motor and sensory nerve segments that were disconnected from endorgans in a rat silicone Y chamber model. The L5 ventral root was used as a pure motor nerve, and the saphenous nerve was used as a sensory nerve. In experiment 1 (n=11), the proximal stump of the L5 ventral root, a 1-cm-long L5 ventral root segment and a saphenous nerve segment were inserted into a silicone Y chamber. In experiment 2 (n=11), the proximal stump of the saphenous nerve, a L5 ventral root segment and a saphenous nerve segment were inserted into a Y chamber. The distance between the nerve stumps was 5 mm. Six weeks later, the number of regenerated myelinated motor and sensory axons was measured and compared in the distal two channels. Motor axons showed no selective regeneration, but sensory axons did.
我们在大鼠硅胶Y室模型中评估了运动和感觉轴突向与终末器官断开连接的远端运动和感觉神经节段的再生选择性。L5腹根用作纯运动神经，隐神经用作感觉神经。在实验1（n = 11）中，将L5腹根的近端残端、一段1厘米长的L5腹根节段和一段隐神经节段插入硅胶Y室。在实验2（n = 11）中，将隐神经的近端残端、一段L5腹根节段和一段隐神经节段插入Y室。神经残端之间的距离为5毫米。六周后，测量并比较远端两个通道中再生的有髓运动和感觉轴突的数量。运动轴突未表现出选择性再生，但感觉轴突表现出了选择性再生。
