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1
Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.抑制细胞中花生四烯酸的释放作为抗炎皮质类固醇的生化作用。
Proc Natl Acad Sci U S A. 1976 May;73(5):1730-4. doi: 10.1073/pnas.73.5.1730.
2
Stimulation of prostaglandin synthesis by bradykinin and thrombin and their mechanisms of action on MC5-5 fibroblasts.缓激肽和凝血酶对前列腺素合成的刺激作用及其对MC5-5成纤维细胞的作用机制。
J Biol Chem. 1976 Sep 25;251(18):5814-6.
3
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Kinetics of glucagon in man: effects of starvation.人体中胰高血糖素的动力学：饥饿的影响。
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7
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Anti-inflammatory agents as inhibitors of prostaglandin synthesis in man.抗炎药物作为人体前列腺素合成的抑制剂。
Med Clin North Am. 1981 Jul;65(4):713-57. doi: 10.1016/s0025-7125(16)31495-x.
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Arachidonic acid level in cellular lipids determines the amount of prostaglandins synthesized during cell growth in tissue culture.细胞脂质中的花生四烯酸水平决定了组织培养中细胞生长期间合成的前列腺素的量。
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Int J Gen Med. 2018 Jul 3;11:265-274. doi: 10.2147/IJGM.S158184. eCollection 2018.

本文引用的文献

1
Studies on lysosomes. II. The effect of cortisone on the release of acid hydrolases from a large granule fraction of rabbit liver induced by an excess of vitamin A.溶酶体研究。II. 可的松对过量维生素A诱导的兔肝大颗粒组分酸性水解酶释放的影响。
J Clin Invest. 1963 May;42(5):661-9. doi: 10.1172/JCI104757.
2
Phospholipid precursors of prostaglandins.前列腺素的磷脂前体。
Biochim Biophys Acta. 1968 Oct 22;164(2):426-9. doi: 10.1016/0005-2760(68)90168-9.
3
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
4
Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids.人皮肤中前列腺素的生物合成及其受皮质类固醇的抑制作用。
Br J Pharmacol. 1972 Sep;46(1):172-5. doi: 10.1111/j.1476-5381.1972.tb06861.x.
5
Lipids of Salmonella typhimurium and Escherichia coli: structure and metabolism.鼠伤寒沙门氏菌和大肠杆菌的脂质：结构与代谢
J Bacteriol. 1968 Mar;95(3):833-43. doi: 10.1128/jb.95.3.833-843.1968.
6
Action of anti-inflammatory steroids on the lytic action of phospholipase C and 2,4,6-trinitrobenzene sulphonic acid on lysosomes.抗炎类固醇对磷脂酶C及2,4,6-三硝基苯磺酸溶酶体溶解作用的影响
Biochem Pharmacol. 1974 Jan 15;23(2):467-70. doi: 10.1016/0006-2952(74)90441-9.
7
Effects of anti-inflammatory drugs on prostaglandin biosynthesis.抗炎药物对前列腺素生物合成的影响。
Nat New Biol. 1972 Jul 26;238(82):104-6. doi: 10.1038/newbio238104a0.
8
Effects of steroid hormones on human polymorphonuclear leukocyte lysosomes.类固醇激素对人多形核白细胞溶酶体的影响。
J Clin Invest. 1974 Oct;54(4):919-25. doi: 10.1172/JCI107832.
9
Biological significance of the prostaglandins.前列腺素的生物学意义。
Recent Prog Horm Res. 1970;26:139-87. doi: 10.1016/b978-0-12-571126-5.50008-x.
10
Superinduction of endogenous type C virus by 5-bromodeoxyuridine from transformed mouse clones.5-溴脱氧尿苷对转化小鼠克隆内源性C型病毒的超诱导作用
Science. 1973 Aug 3;181(4098):443-4. doi: 10.1126/science.181.4098.443.

抑制细胞中花生四烯酸的释放作为抗炎皮质类固醇的生化作用。

Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

作者信息

Hong S L, Levine L

出版信息

Proc Natl Acad Sci U S A. 1976 May;73(5):1730-4. doi: 10.1073/pnas.73.5.1730.

DOI:10.1073/pnas.73.5.1730
PMID:1064044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430374/
Abstract

Serum stimulates the production of prostaglandins by transformed mouse fibroblasts. Hydrocortisone (cortisol) inhibits this stimulation. The half-maximal inhibition occurs at 6x10-9 M. Studies with cells labeled with [3H]arachidonic acid in their lipids show that the stimulation by serum results in the release of arachidonic acid from the cellular lipids, mostly phospholipids. Hydrocrotisone inhibits this release but does not inhibit the production of prostaglandins from exogenously supplied arachidonic acid. This inhibition of arachidonic acid release from phospholipids may be the mechanism for the anti-inflammatory action of corticosteroids.

摘要

血清可刺激转化的小鼠成纤维细胞产生前列腺素。氢化可的松（皮质醇）可抑制这种刺激作用。半数最大抑制浓度为6×10⁻⁹ M。对脂质中标记有[³H]花生四烯酸的细胞进行的研究表明，血清刺激会导致花生四烯酸从细胞脂质（主要是磷脂）中释放出来。氢化可的松可抑制这种释放，但不抑制由外源性提供的花生四烯酸生成前列腺素。这种对花生四烯酸从磷脂中释放的抑制作用可能是皮质类固醇抗炎作用的机制。