接受免疫抑制治疗的白血病儿童中的非典型麻疹感染。

Pullan C R, Noble T C, Scott D J, Wisniewsk K, Gardner P S

Br Med J. 1976 Jun 26;1(6025):1562-5. doi: 10.1136/bmj.1.6025.1562.

One case of giant-cell pneumonia and two of encephalopathy, all due to measles infection in children in leukaemic remission on immunosuppressive treatment, were seen recently. The clinical syndromes were variable and atypical and the antibody responses unpredictable. Conventional doses of pooled immunoglobulin failed to protect the two children to whom it was given. Degeneration rather than inflammation seems to characterise the encephalopathy in immunosuppressed children infected with measles virus.

最近发现1例巨细胞肺炎和2例脑病病例，所有病例均发生在接受免疫抑制治疗且处于白血病缓解期的儿童身上，病因是麻疹感染。临床综合征表现多样且不典型，抗体反应难以预测。常规剂量的混合免疫球蛋白未能保护接受该治疗的两名儿童。在感染麻疹病毒的免疫抑制儿童中，脑病的特征似乎是变性而非炎症。