Fishman M L, Bean S C, Cogan D G
Am J Ophthalmol. 1976 Oct;82(4):571-6. doi: 10.1016/0002-9394(76)90544-4.
Two patients with acute lymphocytic leukemia developed progressive optic nerve and chiasmal lesions eight to nine months after the initiation of identical chemotherapy protocols that included intrathecal medication and prophylactic radiation of only 2,400 rads to the central nervous system. Both patients eventually lost all vision despite additional radiotherapy, and there was no evidence of leukemia involving the central nervous system after acute lymphocytic leukemia was diagnosed. Optic nerve biopsy in one case showed changes consistent with radiation necrosis.
两名急性淋巴细胞白血病患者在开始相同的化疗方案（包括鞘内用药和仅对中枢神经系统进行2400拉德的预防性放疗）八至九个月后，出现了进行性视神经和视交叉病变。尽管进行了额外的放疗，两名患者最终还是完全失明，并且在诊断为急性淋巴细胞白血病后，没有证据表明白血病累及中枢神经系统。其中一例患者的视神经活检显示出与放射性坏死一致的变化。
