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Comparative study of agar diffusion test and the NCCLS macrobroth method for in vitro susceptibility testing of Candida spp.

作者信息

Soni L M, Burattini M N, Pignatari A C, Gompertz O F, Colombo A L

机构信息

Division of Infectious Diseases, Escola Paulista de Medicina-UNIFESP, Brazil.

出版信息

Mycopathologia. 1999;145(3):131-5. doi: 10.1023/a:1007068826861.

DOI:10.1023/a:1007068826861
PMID:10685448
Abstract

We performed a prospective double-blind study to evaluate the correlation between inhibition zones obtained by a disk-diffusion test, using Neo-sensitabs of fluconazole (Rosco Diagnostica), and the MICs generated by the NCCLS macrobroth dilution assay. Eighty clinical isolates, representing 5 of the clinically relevant species of Candida, were tested simultaneously by both methods. A clear inverse correlation was found between the results obtained by both tests (r = -0.69). In addition, there was high degree of agreement between methods in the identification of susceptible isolates. However, the resistance definition by disk-diffusion test had a positive predictive value of only 17%. Our data support the hypothesis that Rosco Fluconazole Neo-sensitabs have potential as a screening test for the identification of Candida isolates susceptible to fluconazole. Resistant isolates should be further investigated by standardized broth procedures.

摘要

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