Identification of deoxymiroestrol as the actual rejuvenating principle of "Kwao Keur", Pueraria mirifica. The known miroestrol may be an artifact.

作者信息

Chansakaow S, Ishikawa T, Seki H, Sekine (née Yoshizawa) K, Okada M, Chaichantipyuth C

机构信息

Faculty of Pharmaceutical Sciences and Chemical Analysis Center, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan.

出版信息

J Nat Prod. 2000 Feb;63(2):173-5. doi: 10.1021/np990547v.

Miroestrol (1) has been isolated previously as an active principle from "Kwao Keur" (Pueraria mirifica), a rejuvenating folk medicine from Thailand. Reinvestigation using bioassay-guided purification has resulted in the isolation of a new potent phytoestrogen, deoxymiroestrol (2). The facile aerial oxidation of 2 into 1 suggests the possibility that 1 may be an artifact.