Gil R R, Lin L Z, Chai H B, Pezzuto J M, Cordell G A
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.
J Nat Prod. 1995 Jun;58(6):848-56. doi: 10.1021/np50120a005.
The EtOAc extract of the whole plant of the Argentinian species Nierembergia aristata showed significant cytotoxicity against eleven different cancer cell lines. In addition to several known compounds, bioassay-guided fractionation led to the isolation of three new cardenolides, 17-epi-11 alpha-hydroxy-6, 7-dehydrostrophanthidin-3-O-beta-boivinopyranoside[1],6, 7-dehydrostrophanthidin-3-O-beta-boivinopyranoside [2], and 6,7-dehydrostrophanthidin-3-O-beta-oleandropyranoside[3], of which the latter demonstrated activity against all the cell lines tested. To our knowledge, this is the first report of the isolation of cardiac glycosides from a species in the Solanaceae.
