Lupton J R, Alster T S
Washington Institute of Dermatologic Laser Surgery, Washington, D.C. 20037, USA.
Dermatol Surg. 2000 Feb;26(2):135-7. doi: 10.1046/j.1524-4725.2000.99202.x.
Injectable hyaluronic acid gel is a non-animal biomaterial used for soft tissue augmentation.
The dermal implantation of this naturally occurring polysaccharide is reported to be well tolerated by patients, with a longer duration in tissue than bovine collagen without any major local or systemic side effects. We report a case of an acute hypersensitivity reaction in a woman after her third injection for improvement of melolabial fold wrinkles.
An adverse granulomatous-like response to the intradermal injection of a modified hyaluronic acid gel is described.
The patient developed indurated and erythematous papulocystic nodules in the melolabial folds bilaterally at the sites of injection.
Injectable hyaluronic acid gel can be associated with severe allergic reactions and patients should be warned of this possible treatment side effect.
可注射透明质酸凝胶是一种用于软组织填充的非动物生物材料。
据报道，这种天然存在的多糖在真皮内植入时患者耐受性良好，在组织中的持续时间比牛胶原蛋白长，且无任何严重的局部或全身副作用。我们报告一例女性患者在第三次注射用于改善唇周皱纹后发生急性过敏反应的病例。
描述了对皮内注射改良透明质酸凝胶产生的不良肉芽肿样反应。
患者双侧唇周褶皱注射部位出现硬结性红斑丘疹囊肿结节。
可注射透明质酸凝胶可能会引发严重过敏反应，应告知患者这种可能的治疗副作用。
