Guida B, De Martino C D, De Martino S D, Tritto G, Patella V, Trio R, D'Agostino C, Pecoraro P, D'Agostino L
Department of Physiology, Nutrition Section, University 'Federico II', Naples, Italy.
Eur J Clin Nutr. 2000 Feb;54(2):155-8. doi: 10.1038/sj.ejcn.1600911.
The aim of this study was to evaluate the effects of an oligoantigenic and histamine-free diet on patients affected with chronic idiopathic urticaria (CIU).
Ten patients with chronic idiopathic urticaria were prescribed an oligoantigenic and histamine-free diet for 21 days, followed by serial and controlled reintroduction of foods during a further 70 days. Modification in clinical illness as well as histamine plasma levels, post-heparin plasma diamine oxidase (DAO) and intestinal permeability were evaluated.
The oligoantigenic and histamine-free diet induced a significant improvement of symptoms (P<0.05). Moreover, CIU patients on free diet showed higher histamine plasma levels (P<0. 05 vs post-diet and vs controls) that fell to control levels during the oligoantigenic and histamine-free diet. Post-heparin plasma diamine oxidase values were slightly reduced and were unchanged during the diet as well as intestinal permeability, which was always normal in all patients.
These data suggest that histamine plays a major role in chronic idiopathic urticaria. The finding of normal intestinal permeability suggests that a morphological damage of intestinal mucosa should be excluded in these patients. However, the presence of low levels of post-heparin plasma diamine oxidase may indicate a subclinical impairment of small bowel enterocyte function that could induce a higher sensitivity to histamine-rich or histamine-producing food. European Journal of Clinical Nutrition (2000) 54, 155-158
本研究旨在评估低抗原且无组胺饮食对慢性特发性荨麻疹（CIU）患者的影响。
10例慢性特发性荨麻疹患者接受低抗原且无组胺饮食21天，随后在接下来的70天内逐步且有控制地重新引入食物。评估临床疾病的变化以及组胺血浆水平、肝素化后血浆二胺氧化酶（DAO）和肠道通透性。
低抗原且无组胺饮食使症状显著改善（P<0.05）。此外，采用自由饮食的CIU患者组胺血浆水平较高（与饮食后及对照组相比，P<0.05），而在低抗原且无组胺饮食期间降至对照水平。肝素化后血浆二胺氧化酶值略有降低，在饮食期间以及肠道通透性方面均无变化，所有患者的肠道通透性始终正常。
这些数据表明组胺在慢性特发性荨麻疹中起主要作用。肠道通透性正常这一发现表明应排除这些患者存在肠黏膜形态学损伤。然而，肝素化后血浆二胺氧化酶水平较低可能表明小肠肠细胞功能存在亚临床损害，这可能导致对富含组胺或能产生组胺的食物更敏感。《欧洲临床营养学杂志》（2000年）54卷，第155 - 158页
