Piérard G E, Nizet J L, Piérard-Franchimont C
Department of Dermatopathology, University Medical Center of Liège, Belgium.
Am J Dermatopathol. 2000 Feb;22(1):34-7. doi: 10.1097/00000372-200002000-00007.
There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens. A control group consisted of 4 women and 11 men showing no evidence of cellulite. The lumpy aspect of the dermohypodermal interface appeared to represent a gender-linked characteristic of the thighs and buttocks without being a specific sign of cellulite. Incipient cellulite identified by the mattress phenomenon was related to the presence of focally enlarged fibrosclerotic strands partitioning the subcutis. Such strands possibly serve as a physiologic buttress against fat herniation limiting the outpouching of fat lobules on pinching the skin. These structures might represent a reactive process to sustained hypodermal pressure caused by fat accumulation. Full-blown cellulite likely represents subjugation of the hypertrophic response when connective tissue is overcome by progressive fat accumulation. Histologic aspects reminiscent of stretch marks are identified within the hypodermal strands, resulting in clinical skin dimpling.
文献中关于橘皮组织的微观解剖学描述存在明显差异。我们通过对39份尸检标本进行显微镜检查，重新审视了这种常见的女性皮肤状况。一个对照组由4名女性和11名男性组成，他们没有橘皮组织的迹象。真皮-皮下组织界面的块状外观似乎代表了大腿和臀部与性别相关的特征，而不是橘皮组织的特定标志。通过床垫现象确定的初期橘皮组织与皮下存在局灶性增大的纤维硬化束有关。这些束可能作为一种生理支撑，防止脂肪疝出，限制捏皮肤时脂肪小叶的突出。这些结构可能代表了对脂肪堆积引起的持续皮下压力的一种反应过程。成熟的橘皮组织可能代表当结缔组织被逐渐积累的脂肪压倒时，肥大反应的屈服。在皮下束中发现了类似妊娠纹的组织学特征，导致临床皮肤出现凹陷。
