Gordon J, Smith J L
Clin Exp Immunol. 1978 Feb;31(2):244-50.
Neoplastic cell preparations from four patients with clinically and morphologically well-defined leukaemic reticuloendotheliosis (LRE) were investigated for their capacity to synthesize immunoglobulin in vitro. Neoplastic cells from all cases synthesized immunoglobulin of the same light chain class as expressed at their cell surface. Labelled IgM and IgD were identified in cell lysates while free light chain was the predominant labelled immunoglobulin product in the LRE culture supernatants. The capacity of LRE cells to synthesize immunoglobulin and free light chain was similar to that of neoplastic cells from patients with chronic lymphocytic leukaemia, and provides further evidence for the B-lymphocyte origin of the neoplastic cells in LRE.
对4例临床和形态学上明确诊断为白血病性网状内皮细胞增生症（LRE）患者的肿瘤细胞制剂进行体外合成免疫球蛋白能力的研究。所有病例的肿瘤细胞合成的免疫球蛋白轻链类别与其细胞表面表达的相同。在细胞裂解物中鉴定出标记的IgM和IgD，而游离轻链是LRE培养上清液中主要的标记免疫球蛋白产物。LRE细胞合成免疫球蛋白和游离轻链的能力与慢性淋巴细胞白血病患者的肿瘤细胞相似，这为LRE中肿瘤细胞的B淋巴细胞起源提供了进一步证据。
