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白血病性网状内皮细胞增多症中肿瘤细胞的游离免疫球蛋白轻链合成

Free immunoglobulin light chain synthesis by neoplastic cells in leukaemic reticuloendotheliosis.

作者信息

Gordon J, Smith J L

出版信息

Clin Exp Immunol. 1978 Feb;31(2):244-50.

PMID:417885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541216/
Abstract

Neoplastic cell preparations from four patients with clinically and morphologically well-defined leukaemic reticuloendotheliosis (LRE) were investigated for their capacity to synthesize immunoglobulin in vitro. Neoplastic cells from all cases synthesized immunoglobulin of the same light chain class as expressed at their cell surface. Labelled IgM and IgD were identified in cell lysates while free light chain was the predominant labelled immunoglobulin product in the LRE culture supernatants. The capacity of LRE cells to synthesize immunoglobulin and free light chain was similar to that of neoplastic cells from patients with chronic lymphocytic leukaemia, and provides further evidence for the B-lymphocyte origin of the neoplastic cells in LRE.

摘要

对4例临床和形态学上明确诊断为白血病性网状内皮细胞增生症（LRE）患者的肿瘤细胞制剂进行体外合成免疫球蛋白能力的研究。所有病例的肿瘤细胞合成的免疫球蛋白轻链类别与其细胞表面表达的相同。在细胞裂解物中鉴定出标记的IgM和IgD，而游离轻链是LRE培养上清液中主要的标记免疫球蛋白产物。LRE细胞合成免疫球蛋白和游离轻链的能力与慢性淋巴细胞白血病患者的肿瘤细胞相似，这为LRE中肿瘤细胞的B淋巴细胞起源提供了进一步证据。

相似文献

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Free immunoglobulin light chain synthesis by neoplastic cells in leukaemic reticuloendotheliosis.白血病性网状内皮细胞增多症中肿瘤细胞的游离免疫球蛋白轻链合成
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本文引用的文献

1
Leukemic reticuloendotheliosis.白血病性网状内皮增生症
Blood. 1958 Jul;13(7):609-30.
2
Chronic reticulolymphocytic leukemia. Reclassification of "leukemic reticuloendotheliosis" through functional characterization of the circulating mononuclear cells.慢性网状淋巴细胞白血病。通过循环单核细胞的功能特性对“白血病性网状内皮细胞增生症”进行重新分类。
Am J Med. 1969 Jul;47(1):149-62. doi: 10.1016/0002-9343(69)90249-6.
3
Hairy cell leukemia: proliferation of a cell with phagocytic and B-lymphocyte properties.毛细胞白血病：一种具有吞噬细胞和B淋巴细胞特性的细胞增殖。
Scand J Immunol. 1974;3(6):847-51. doi: 10.1111/j.1365-3083.1974.tb01322.x.
4
The B-lymphocyte nature of the hairy cell of leukaemic reticuloendotheliosis.白血病性网状内皮增生症中毛细胞的B淋巴细胞性质。
Br J Haematol. 1974 Jan;26(1):29-37. doi: 10.1111/j.1365-2141.1974.tb00446.x.
5
Leukemic reticuloendotheliosis: presence of a receptor for cytophilic antibody.白血病性网状内皮增生症：嗜细胞性抗体受体的存在。
Am J Med. 1974 Jul;57(1):108-14. doi: 10.1016/0002-9343(74)90775-x.
6
[Hairy cell leukemia (tricholeukocyte leukemia). Clinical and cytological (author's transl)].
Nouv Rev Fr Hematol. 1973 Sep-Oct;13(5):609-40.
7
Leukaemic reticuloendotheliosis: a morphological and immunological study of four cases.白血病性网状内皮细胞增生症：4例的形态学与免疫学研究
J Clin Pathol. 1974 Dec;27(12):967-72. doi: 10.1136/jcp.27.12.967.
8
Cell membrane IgD: demonstration of IgD on human lymphocytes by enzyme-catalyzed iodination and comparison with cell surface Ig of mouse, guinea pig, and rabbit.细胞膜IgD：通过酶催化碘化法证明人淋巴细胞上存在IgD，并与小鼠、豚鼠和兔的细胞表面Ig进行比较。
J Immunol. 1976 Apr;116(4):1173-81.
9
Hairy cell leukemia: functional, immunologic, kinetic, and ultrastructural characterization.毛细胞白血病：功能、免疫、动力学及超微结构特征
Blood. 1975 Oct;46(4):495-507.
10
Leukemic reticuloendotheliosis. A study of the origin of the malignant cell.白血病性网状内皮增生症。恶性细胞起源的研究。
Am J Med. 1975 Sep;59(3):411-6. doi: 10.1016/0002-9343(75)90400-3.

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