Hannam-Harris A C, Gordon J, Smith J L
J Immunol. 1980 Nov;125(5):2177-81.
Immunoglobulin synthesis has been investigated in 55 cases of B lymphocytic disease. Free light chain was the predominant product of Ig synthesis and the sole secreted Ig product from neoplasms lacking surface Ig or expressing sparse surface IgM as detected by fluorescent-labeled antibody. In contrast, neoplastic cells expressing strong surface IgM or IgG synthesized and secreted balanced amounts of heavy and light chain. Intermediate patterns of synthesis were shown by neoplastic cells expressing IgM with IgD. These patterns of synthesis occurred irrespective of the disease entity and are discussed in relation to models of B cell maturation.
对55例B淋巴细胞疾病患者的免疫球蛋白合成情况进行了研究。游离轻链是免疫球蛋白合成的主要产物，也是通过荧光标记抗体检测到的缺乏表面免疫球蛋白或表达稀疏表面IgM的肿瘤唯一分泌的免疫球蛋白产物。相比之下，表达强表面IgM或IgG的肿瘤细胞合成并分泌等量的重链和轻链。表达IgM和IgD的肿瘤细胞呈现出中间合成模式。这些合成模式与疾病实体无关，并结合B细胞成熟模型进行了讨论。
