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本文引用的文献

1
Nucleotide sequence of IS1542, an insertion sequence identified within VanA glycopeptide resistance elements of enterococci.IS1542的核苷酸序列，一种在肠球菌VanA糖肽抗性元件中鉴定出的插入序列。
FEMS Microbiol Lett. 1999 Apr 15;173(2):341-6. doi: 10.1111/j.1574-6968.1999.tb13523.x.
2
Molecular diversity and evolutionary relationships of Tn1546-like elements in enterococci from humans and animals.人和动物来源肠球菌中Tn1546样元件的分子多样性及进化关系
Antimicrob Agents Chemother. 1999 Mar;43(3):483-91. doi: 10.1128/AAC.43.3.483.
3
Variation in structure and location of VanA glycopeptide resistance elements among enterococci from a single patient.来自一名患者的肠球菌中VanA糖肽抗性元件的结构和位置变异。
J Clin Microbiol. 1999 Mar;37(3):818-20. doi: 10.1128/JCM.37.3.818-820.1999.
4
Molecular analysis of diverse elements mediating VanA glycopeptide resistance in enterococci.介导肠球菌VanA糖肽抗性的多种因素的分子分析。
J Antimicrob Chemother. 1998 Nov;42(5):605-12. doi: 10.1093/jac/42.5.605.
5
Diversity of VanA glycopeptide resistance elements in enterococci from humans and nonhuman sources.来自人类和非人类来源的肠球菌中VanA糖肽抗性元件的多样性。
Antimicrob Agents Chemother. 1998 Mar;42(3):502-8. doi: 10.1128/AAC.42.3.502.
6
Molecular analysis of Tn1546 in Enterococcus faecium isolated from animals and humans.从动物和人类分离出的屎肠球菌中Tn1546的分子分析。
J Clin Microbiol. 1998 Feb;36(2):437-42. doi: 10.1128/JCM.36.2.437-442.1998.
7
Identification and characterization of IS1476, an insertion sequence-like element that disrupts VanY function in a vancomycin-resistant Enterococcus faecium strain.IS1476的鉴定与特性分析，IS1476是一种插入序列样元件，可破坏一株耐万古霉素屎肠球菌中VanY的功能。
Antimicrob Agents Chemother. 1997 Aug;41(8):1805-7. doi: 10.1128/AAC.41.8.1805.
8
Plasmid-mediated vanB glycopeptide resistance in enterococci.肠球菌中质粒介导的万古霉素B糖肽耐药性
Microb Drug Resist. 1995 Fall;1(3):235-40. doi: 10.1089/mdr.1995.1.235.
9
Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.Tn1546的特性分析，Tn1546是一种与Tn3相关的转座子，通过在屎肠球菌BM4147中合成脂肽类肽聚糖前体赋予糖肽抗性。
J Bacteriol. 1993 Jan;175(1):117-27. doi: 10.1128/jb.175.1.117-127.1993.
10
Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from the northeastern United States.美国东北部肠球菌临床分离株中vanA基因簇的异质性
Antimicrob Agents Chemother. 1995 Feb;39(2):362-8. doi: 10.1128/AAC.39.2.362.

插入序列移动对粪肠球菌中VanA糖肽抗性元件结构的影响。

Effects of the movement of insertion sequences on the structure of VanA glycopeptide resistance elements in Enterococcus faecium.

作者信息

Darini A L, Palepou M F, Woodford N

机构信息

Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom.

出版信息

Antimicrob Agents Chemother. 2000 May;44(5):1362-4. doi: 10.1128/AAC.44.5.1362-1364.2000.

DOI:10.1128/AAC.44.5.1362-1364.2000
PMID:10770779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89872/
Abstract

A Tn1546-related element with IS1216V at position 8839 underwent a structural change after storage of the host strain of Enterococcus faecium at 4 degrees C. The element acquired IS1542 at position 3932, nucleotides 8732 to 8831 were deleted, and the first 3417 nucleotides were lost and replaced by an inverted copy of the IS1216V-vanY-vanZ-inverted-repeat block from the 3' end. Insertion sequence movement is likely to play a key role in the evolution of VanA resistance elements.

摘要

一个在8839位带有IS1216V的Tn1546相关元件，在粪肠球菌宿主菌株于4℃保存后发生了结构变化。该元件在3932位获得了IS1542，8732至8831位核苷酸被删除，前3417个核苷酸丢失并被来自3'端的IS1216V-vanY-vanZ-反向重复序列块的反向拷贝所取代。插入序列移动可能在VanA抗性元件的进化中起关键作用。