Larsen S B, Joffe M, Bonde J P
Arbejdsmedicinsk klinik, Arhus Universitetshospital, Arhus Kommunehospital.
Ugeskr Laeger. 1999 Nov 22;161(47):6480-4.
The aim of this study was to examine time to pregnancy among farmers who used pesticides (traditional farmers) and farmers who did not (organic farmers). A total of 904 men, selected from the Danish Ministry of Agriculture lists of traditional and organic farmers, participated in telephone interviews. The participation rate was 84%. Information was collected on "time to pregnancy" for the youngest child, exposure to pesticides and potential confounders. Using the discrete analogue of the Cox Regression Model (including potential confounders: male and female smoking, female age, parity and contraceptive method), the fecundability ratio between traditional farmers using pesticides and organic farmers was 1.03 (95% CI: 0.75-1.40). In the group of farmers who sprayed with pesticides, none of the characteristics related to the use of pesticides could account for the variation in time to pregnancy. No overall effect of pesticides on male fecundability could be demonstrated in this retrospective study among Danish farmers.
本研究的目的是调查使用农药的农民(传统农民)和不使用农药的农民(有机农民)的受孕时间。从丹麦农业部传统农民和有机农民名单中选取的904名男性参与了电话访谈。参与率为84%。收集了关于最年幼子女的“受孕时间”、农药暴露情况和潜在混杂因素的信息。使用Cox回归模型的离散模拟(包括潜在混杂因素:男性和女性吸烟情况、女性年龄、产次和避孕方法),使用农药的传统农民与有机农民之间的生育力比为1.03(95%置信区间:0.75 - 1.40)。在喷洒农药的农民群体中,与农药使用相关的任何特征都无法解释受孕时间的差异。在这项针对丹麦农民的回顾性研究中,未发现农药对男性生育力有总体影响。