Lauria Laura, Settimi Laura, Spinelli Angela, Figà-Talamanca Irene
National Institute of Health, Viale Regina Elena 299, Rome 00161, Italy.
Reprod Toxicol. 2006 Oct;22(3):425-30. doi: 10.1016/j.reprotox.2005.12.011. Epub 2006 Feb 17.
The aim of the study was to evaluate the possible effect of maternal work in greenhouses, as characterised by potentially high exposure to pesticides, on female fertility. Nine hundred and ten women active in 34 greenhouse flower growing enterprises in 1998-2000, with at least one pregnancy, and aged less than 50 years were identified. Seven hundred and seventeen (79%) agreed to be interviewed and reported 1699 pregnancies, of which 713 had complete information on time to pregnancy and occupation. These pregnancies were classified as exposed or non-exposed according to the maternal occupation in greenhouses at the moment of conception and analysed using logistic regression and survival analysis methods. We found a slightly higher proportion of pregnancies with delayed conception (more than 6 months) in the exposed group. However, after adjustment for confounding variables, the estimated hazard ratio for reduced fertility among the exposed was not significantly different to that of the non-exposed pregnancies (HR=0.96, 95%CI: 0.81, 1.13). A significant reduction in fecundability was observed in older women and with a daily consumption of one or more alcoholic beverages or cups of tea.
本研究的目的是评估母亲在温室工作(其特点是可能高暴露于农药)对女性生育能力的潜在影响。在1998年至2000年期间,确定了910名活跃于34家温室花卉种植企业、至少有过一次怀孕且年龄小于50岁的女性。717名(79%)同意接受访谈,并报告了1699次怀孕情况,其中713次怀孕有关于受孕时间和职业的完整信息。这些怀孕情况根据受孕时母亲在温室中的职业分为暴露组或非暴露组,并使用逻辑回归和生存分析方法进行分析。我们发现暴露组中受孕延迟(超过6个月)的怀孕比例略高。然而,在对混杂变量进行调整后,暴露组中生育能力降低的估计风险比与非暴露组怀孕的风险比无显著差异(风险比=0.96,95%置信区间:0.81,1.13)。在年龄较大的女性以及每天饮用一种或多种酒精饮料或茶的女性中,观察到生育力显著降低。