Lakos G, Kiss E, Regeczy N, Tarjan P, Soltesz P, Zeher M, Bodolay E, Szucs G, Szakony S, Sipka S, Szegedi G
3rd Department of Medicine, and the Institute of Clinical Biochemistry and Molecular Pathology, University Medical School of Debrecen, Hungary.
J Rheumatol. 2000 Apr;27(4):924-9.
To investigate the relationship between antiprothrombin (aPT) and antiannexin V (aANX) autoantibodies of IgG isotype and thrombosis in patients with systemic autoimmune diseases. To compare the clinical relevance of these antibodies to that of anticardiolipin (aCL), anti-beta2-glycoprotein I antibodies (anti-beta2-GPI), and lupus anticoagulant (LAC).
Serum IgG aPT, aANX, aCL, and anti-beta2-GPI levels were measured by solid phase enzyme immunoassay in the sera of 70 patients with systemic autoimmune diseases, 35 with antiphospholipid syndrome (APS) and 35 without APS. Medical records were analyzed, and associations of the antibodies with clinical features of APS were assessed.
Patients with APS had higher frequency of aPT (p = 0.001) and aANX (p = 0.002) compared to patients without APS. Thrombotic events occurred more frequently in those with aPT or aANX than those without (p = 0.005, p = 0.006, respectively). The presence of aPT and aANX was found to be highly specific for APS.
Measurement of aPT and aANX antibodies may be of value in confirming the diagnosis of APS, and in evaluating risk of venous and arterial thrombosis in patients with systemic autoimmune diseases.
研究全身性自身免疫性疾病患者中免疫球蛋白G同种型的抗凝血酶原（aPT）和抗膜联蛋白V（aANX）自身抗体与血栓形成之间的关系。比较这些抗体与抗心磷脂（aCL）、抗β2-糖蛋白I抗体（抗β2-GPI）和狼疮抗凝物（LAC）的临床相关性。
采用固相酶免疫测定法检测70例全身性自身免疫性疾病患者、35例抗磷脂综合征（APS）患者和35例非APS患者血清中的IgG aPT、aANX、aCL和抗β2-GPI水平。分析病历，并评估这些抗体与APS临床特征的相关性。
与非APS患者相比，APS患者中aPT（p = 0.001）和aANX（p = 0.002）的出现频率更高。aPT或aANX阳性患者的血栓形成事件比阴性患者更频繁（分别为p = 0.005，p = 0.006）。发现aPT和aANX的存在对APS具有高度特异性。
检测aPT和aANX抗体可能有助于确诊APS，并评估全身性自身免疫性疾病患者发生静脉和动脉血栓形成的风险。
