小鼠对φX174的免疫反应。百日咳疫苗对B细胞免疫的增强作用及对T细胞辅助的抑制作用。
The immune response of mice to phiX174. The potentiation of B-cell immunity and the suppression of T-cell help by pertussis vaccine.
作者信息
Dresser D W, Tao T W
出版信息
Immunology. 1975 Mar;28(3):443-50.
Abstract
The primary and secondary responses to phiX174 have been studied in T cell-deprived (T- minus) and control CBA mice including sham-operated (T+) and normal mice. The effect of pertussis on the immune response of these mice has been measured. It is concluded that: (1) the gammaG and memory responses to phiX are produced in T- minus mice even though greatly reduced in comparison with T+ and normal mice; (2) pertussis appears to enhance the gammaG response in T- minus mice while suppressing it in T+ and normal mice.
摘要
已在去除T细胞（T-）的和对照CBA小鼠（包括假手术的（T+）和正常小鼠）中研究了对噬菌体φX174的初次和二次反应。已测定百日咳对这些小鼠免疫反应的影响。得出以下结论：（1）去除T细胞的小鼠中产生了对噬菌体φX的γG和记忆反应，尽管与T+和正常小鼠相比大幅降低；（2）百日咳似乎增强了去除T细胞的小鼠中的γG反应，同时抑制了T+和正常小鼠中的γG反应。
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