用人同种抗血清检测B淋巴细胞培养细胞系的特异性抗原。
Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera.
作者信息
Mann D L, Abelson L, Harris S, Amos D B
出版信息
J Exp Med. 1975 Jul 1;142(1):84-9. doi: 10.1084/jem.142.1.84.
Abstract
Human sera were tested for cytotoxicity to pairs of long-term tissue-cultured cell lines. Each pair had been derived from the same individual and one of the pairs possessed the characteristics of either "T" or "B" cells. The alloantisera used were HL-A-typing reagents or sera obtained from Amish multiparas. Selected cytotoxicity was found against the B-cell lines by direct testing. Cytotoxicity was abolished by absorption with B-cell line but not by absorption with the T-cell lines. The results suggest that a group of allotypic antigens may be expressed exculsively on human B cells.
摘要
检测人血清对多对长期组织培养细胞系的细胞毒性。每对细胞系都来自同一个体，其中一对具有“T”或“B”细胞的特征。所用的同种抗血清是HL - A分型试剂或从阿米什多产妇获得的血清。通过直接检测发现对B细胞系有特异性细胞毒性。用B细胞系吸收可消除细胞毒性，而用T细胞系吸收则不能。结果表明，一组同种异型抗原可能仅在人B细胞上表达。
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