Mulaisho C, Abdou N I, Utiger R D
J Clin Endocrinol Metab. 1975 Aug;41(2):266-70. doi: 10.1210/jcem-41-2-266.
Lymphocytes capable of forming nonimmune (E) and immune (EAC) rosettes with sheep erythrocytes and lymphocyte reactivity to phytohemagglutinin were determined in normal subjects, in patients with hyperthyroidism due to Graves' disease and in patients with hypothyroidism with and without goiter. Neither patient group differed from the normal subjects either in regard to lymphocyte count, the proportion of thymus dependent (t) lymphocytes forming nonimmune or bone marrow-dependnet (B) lymphocytes forming immune rosettes or lymphocyte reactivity to phytohemagglutinin. These results fail to provide evidence that these disorders are associated with an immune abnormality with increased or abnormal T cells in peripheral blood.
在正常受试者、患有格雷夫斯病的甲状腺功能亢进患者以及伴有或不伴有甲状腺肿的甲状腺功能减退患者中，测定了能够与绵羊红细胞形成非免疫（E）和免疫（EAC）玫瑰花结的淋巴细胞以及淋巴细胞对植物血凝素的反应性。无论是哪一组患者，在淋巴细胞计数、形成非免疫玫瑰花结的胸腺依赖性（t）淋巴细胞比例或形成免疫玫瑰花结的骨髓依赖性（B）淋巴细胞比例，以及淋巴细胞对植物血凝素的反应性方面，均与正常受试者无差异。这些结果未能提供证据表明这些疾病与外周血中T细胞增加或异常的免疫异常有关。
