库欣综合征的免疫危害。
The immunological hazard of Cushing's syndrome.
作者信息
Britton S, Thorén M, Sjoberg H E
出版信息
Br Med J. 1975 Dec 20;4(5998):678-80. doi: 10.1136/bmj.4.5998.678.
Abstract
A 24-year-old woman was found to have cryptococcal meningitis and Cushing's syndrome due to an adrenal adenoma. Her meningitis was successfully arrested with fluorouracil. Treatment with metyrapone decreased her cortisol production and produced clinical remission of Cushing's syndrome. On admission her peripheral T lymphocytes were few and hyporeactive. When the overproduction of cortisol ceased the numbers of T lymphocytes and their reactivity returned to normal and she developed in-vitro lymphocyte responsiveness to the cryptococci.
摘要
一名24岁女性被发现患有新型隐球菌性脑膜炎和由肾上腺腺瘤引起的库欣综合征。她的脑膜炎通过氟尿嘧啶成功得到控制。甲吡酮治疗降低了她的皮质醇分泌，并使库欣综合征临床缓解。入院时她的外周血T淋巴细胞数量少且反应性低。当皮质醇分泌过多停止后，T淋巴细胞数量及其反应性恢复正常，并且她在体外对新型隐球菌产生了淋巴细胞反应性。
相似文献
1
The immunological hazard of Cushing's syndrome.库欣综合征的免疫危害。
Br Med J. 1975 Dec 20;4(5998):678-80. doi: 10.1136/bmj.4.5998.678.
2
Cushing's syndrome in pregnancy--treatment with metyrapone.妊娠期库欣综合征——甲吡酮治疗
Clin Endocrinol (Oxf). 1982 Mar;16(3):283-93. doi: 10.1111/j.1365-2265.1982.tb00718.x.
3
Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy.妊娠期间继发于肾上腺腺瘤的库欣综合征：甲吡酮治疗与腹腔镜肾上腺切除术
J Endocrinol Invest. 2006 Feb;29(2):164-7. doi: 10.1007/BF03344091.
4
Aminoglutethimide and metyrapone in the management of Cushing's syndrome.氨鲁米特和甲吡酮在库欣综合征治疗中的应用
Acta Endocrinol (Copenh). 1985 Aug;109(4):451-7. doi: 10.1530/acta.0.1090451.
5
Cushing's syndrome caused by a metyrapone responsive adrenocortical adenoma.美替拉酮反应性肾上腺皮质腺瘤引起的库欣综合征
J Clin Endocrinol Metab. 1970 Aug;31(2):199-203. doi: 10.1210/jcem-31-2-199.
6
7
Coexistence of pituitary adrenocorticotropin-dependent Cushing's syndrome with a solitary adrenal adenoma.垂体促肾上腺皮质激素依赖性库欣综合征与孤立性肾上腺腺瘤并存。
J Clin Endocrinol Metab. 1980 May;50(5):961-6. doi: 10.1210/jcem-50-5-961.
8
Cushing's syndrome--transitory immune deficiency state?库欣综合征——短暂的免疫缺陷状态？
Postgrad Med J. 1986 Jul;62(729):657-9. doi: 10.1136/pgmj.62.729.657.
9
[Adrenal cortex polymicroadenomatosis in Cushing's syndrome].[库欣综合征中的肾上腺皮质多微腺瘤病]
Ann Endocrinol (Paris). 1973 Mar-Apr;34(2):206-15.
10
Preoperative management of Cushing's syndrome with metyrapone for severe psychiatric disturbances.用甲吡酮对库欣综合征进行术前管理以治疗严重精神障碍。
Int J Urol. 2008 Apr;15(4):361-2. doi: 10.1111/j.1442-2042.2008.01995.x.
引用本文的文献
1
Unexpected exacerbation of cryptococcal meningitis after unilateral adrenalectomy in a PMAH patient: a case report and literature review.特发性先天性肾上腺皮质增生症患者单侧肾上腺切除术后隐球菌性脑膜炎恶化：病例报告及文献复习。
BMC Endocr Disord. 2023 Sep 18;23(1):199. doi: 10.1186/s12902-023-01457-5.
2
Cushing Disease: Medical and Surgical Considerations.库欣病：医学和手术考虑因素。
Otolaryngol Clin North Am. 2022 Apr;55(2):315-329. doi: 10.1016/j.otc.2021.12.006. Epub 2022 Mar 4.
3
Assessing the immune state of dogs suffering from pituitary gland dependent hyperadrenocorticism by determining changes in peripheral lymphocyte subsets.评估垂体依赖性库欣病犬的免疫状态，通过检测外周血淋巴细胞亚群的变化。
Vet Res Commun. 2009 Oct;33(7):757-69. doi: 10.1007/s11259-009-9224-5. Epub 2009 May 22.
4
Functioning adrenal black adenoma with pulmonary and cutaneous cryptococcosis: a case report and review of English literature.功能性肾上腺黑色腺瘤合并肺和皮肤隐球菌病：一例报告及英文文献复习
J Endocrinol Invest. 2001 Nov;24(10):816-9. doi: 10.1007/BF03343933.
5
Cushing's syndrome complicated by multiple opportunistic infections.库欣综合征并发多种机会性感染。
J Endocrinol Invest. 1998 May;21(5):329-33. doi: 10.1007/BF03350337.
6
Cushing's syndrome--transitory immune deficiency state?库欣综合征——短暂的免疫缺陷状态？
Postgrad Med J. 1986 Jul;62(729):657-9. doi: 10.1136/pgmj.62.729.657.
7
Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.内源性皮质醇调节免疫球蛋白E依赖性迟发相反应。
J Clin Invest. 1992 Aug;90(2):596-603. doi: 10.1172/JCI115898.
8
Network of immune-neuroendocrine interactions.免疫-神经内分泌相互作用网络
Clin Exp Immunol. 1977 Jan;27(1):1-12.
9
Premorbid psychological factors as related to cancer incidence.与癌症发病率相关的病前心理因素。
J Behav Med. 1978 Mar;1(1):45-133. doi: 10.1007/BF00846586.
本文引用的文献
1
DIAGNOSIS OF CUSHING'S SYNDROME; SINGLE DOSE DEXAMETHASONE SUPPRESSION TEST.库欣综合征的诊断；单次剂量地塞米松抑制试验
Arch Intern Med. 1965 Aug;116:172-6. doi: 10.1001/archinte.1965.03870020012006.
2
A FOUR-DAY CORTICOTROPHIN-SUPPRESSION TEST. STUDIES IN CUSHING'S SYNDROME AND IN NON CUSHING SUBJECTS WITH RELATED SYMPTOMS.一项为期四天的促肾上腺皮质激素抑制试验。库欣综合征及有相关症状的非库欣受试者的研究。
Acta Endocrinol (Copenh). 1965 Jan;48:147-62.
3
The specificity of fluorometric corticoid determinations.荧光法测定皮质类固醇的特异性。
Clin Chim Acta. 1962 Jul;7:475-80. doi: 10.1016/0009-8981(62)90087-6.
4
Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome.垂体-肾上腺抑制试验在库欣综合征诊断中的应用
J Clin Endocrinol Metab. 1960 Dec;20:1539-60. doi: 10.1210/jcem-20-12-1539.
5
The interpretation of steroid half-life values.类固醇半衰期值的解读。
J Clin Endocrinol Metab. 1959 Jul;19(7):854-6. doi: 10.1210/jcem-19-7-854.
6
Indirect analysis of corticosteroids. I. The determination of 17-hydroxycorticosteroids.皮质类固醇的间接分析。I. 17-羟皮质类固醇的测定。
Biochem J. 1955 Jul;60(3):453-60. doi: 10.1042/bj0600453.
7
Human lymphocyte subpopulations. Effect of corticosteroids.人类淋巴细胞亚群。皮质类固醇的作用。
J Clin Invest. 1974 Feb;53(2):565-71. doi: 10.1172/JCI107591.
8
Evidence for a small pool of immunocompetent cells in the mouse thymus.小鼠胸腺中存在少量免疫活性细胞的证据。
Exp Cell Res. 1969 Oct;57(2):185-92. doi: 10.1016/0014-4827(69)90140-2.
9
The response of lymphocytes from tuberculin-positive or negative humans to various doses of PPD-tuberculin in vitro.结核菌素阳性或阴性人群的淋巴细胞在体外对不同剂量的纯蛋白衍生物结核菌素的反应。
Cell Immunol. 1972 Mar;3(3):493-500. doi: 10.1016/0008-8749(72)90254-7.
10
The effect of in vivo hydrocortisone on subpopulations of human lymphocytes.体内氢化可的松对人淋巴细胞亚群的影响。
J Clin Invest. 1974 Jan;53(1):240-6. doi: 10.1172/JCI107544.
Zotero 插件