Stinson R S, Mashaly M M, Glick B
Immunology. 1979 Apr;36(4):769-74.
The elaboration of various inhibitory factors by sensitized lymphocytes has been reported for both mammals and birds. Until recently, the ability of the B cell to elaborate these had been questioned by a number of investigators. We have demonstrated the release of a lymphocyte inhibitory factor from the avian thymus and bursal lymphocyte. The avian thrombocyte is active in haemostasis as well as being a phagocytic cell. We have demonstrated that the ability of the thrombocyte to migrate, significantly exceeded that of thymic lymphocytes. Sensitized T and B cells, as well as activated supernatants from these cells, were capable of inhibiting thrombocyte migration. Treatment of sensitized B cells with anti-T-cell serum plus complement failed to eliminate this cell's ability to block thrombocyte migration. These data attribute the capability of elaborating a thrombocyte migration inhibitory factor to both the avian thymic and bursal lymphocyte, and attribute a degree of maturity to these cells not previously demonstrated.
对于哺乳动物和鸟类，均有关于致敏淋巴细胞产生各种抑制因子的报道。直到最近，许多研究者对B细胞产生这些抑制因子的能力提出了质疑。我们已经证明，禽类胸腺和法氏囊淋巴细胞能释放一种淋巴细胞抑制因子。禽类血小板在止血过程中发挥作用，同时也是一种吞噬细胞。我们已经证明，血小板的迁移能力显著超过胸腺淋巴细胞。致敏的T细胞和B细胞以及这些细胞的活化上清液均能够抑制血小板迁移。用抗T细胞血清加补体处理致敏B细胞，未能消除该细胞阻断血小板迁移的能力。这些数据表明，禽类胸腺和法氏囊淋巴细胞均具有产生血小板迁移抑制因子的能力，并且表明这些细胞具有一定程度的成熟度，这是之前未被证实的。
