从日本红豆杉（Taxus cuspidata）种子中分离出的三种新紫杉烷类化合物。

Three new taxoids from the seeds of Japanese yew, Taxus cuspidata.

作者信息

Shi Q W, Oritani T, Zhao D, Murakami R, Oritani T

出版信息

Planta Med. 2000 Apr;66(3):294-9. doi: 10.1055/s-2000-8565.

DOI:10.1055/s-2000-8565

Abstract

Five taxane diterpenoids were isolated from the seeds of the Japanese yew, Taxus cuspidata Sieb. et Zucc. The structures were established as 2 alpha,7 beta,13 alpha-triacetoxy-5 alpha-(3'-dimethylamino-3'-phenyl)-propionyloxy-2(3-->20)-aboe+ ++-taxa-9,10-dione (1) and 2 alpha,7 beta,9 alpha,10 beta-tetraacetoxy-5 alpha-[(2R,3S),N,N-dimethyl-3-phenylisoseryloxy]-taxa-4(20),11- dien-13-one (2), 2 alpha, 9 alpha, 10 beta-triacetoxy-5 alpha-cinnamoxy-taxa-4(20),11-diene-13 alpha-ol (3), taxezopidine J (4), and taxuspine D (5) on the basis of 1D, 2D NMR, and MS spectral analysis. Compounds 1, 2, and 3 are new compounds.

摘要

从日本红豆杉（Taxus cuspidata Sieb. et Zucc.）的种子中分离出了五种紫杉烷二萜类化合物。通过一维、二维核磁共振和质谱光谱分析，确定其结构分别为2α,7β,13α-三乙酰氧基-5α-(3'-二甲基氨基-3'-苯基)-丙酰氧基-2(3→20)-环氧紫杉-9,10-二酮（1）、2α,7β,9α,10β-四乙酰氧基-5α-[(2R,3S),N,N-二甲基-3-苯基异丝氨酰氧基]-紫杉-4(20),11-二烯-13-酮（2）、2α,9α,10β-三乙酰氧基-5α-肉桂酰氧基-紫杉-4(20),11-二烯-13α-醇（3）、紫杉匹定J（4）和紫杉松D（5）。化合物1、2和3为新化合物。