Bonetti A, Solito F, Carmosino G, Bargossi A M, Fiorella P L
Chair of Sport Medicine, University of Parma, Italy.
J Sports Med Phys Fitness. 2000 Mar;40(1):51-7.
Coenzyme Q10 (CoQ10) plays an important role in oxidative mithocondrial phosphorylation and prevents lipid peroxidation in biological membranes. During sustained physical exercise, reactive oxygen species (ROS) production increase through several mechanism; one of them is the purine nucleotide cycle activation by shifting xanthine-dehydrogenase to xanthine-oxidase during AMP breakdown. The aim of this study was to evaluate the effect of CoQ10 treatment on aerobic power.
according to a single blind study design, 28 health male cyclists were randomized into two groups (CoQ10 or placebo) and remained on treatments for eight weeks; there were 5 drop-outs and only 23 subjects were completely evaluated. Before and at the end of the eight weeks, cyclists underwent cardiopulmonary exercise testing.
a software system performed the necessary calculations to obtain the following parameters: oxygen uptake, CO2 production, minute ventilation, oxygen ventilatory equivalent, carbon dioxide ventilatory equivalent, oxygen pulse. Finally oxygen peak and anaerobic threshold were determined. Moreover blood inosine, hypoxanthine, xanthine, lactate and CoQ10 levels were measured before and immediately after each test.
The results of this study showed that at the end of the eight weeks there was no difference between the two groups concerning physiological and metabolic parameters, but muscular exhaustion was reached at higher workloads in the CoQ10 group.
In our experience ubidecarenone oral treatment does not improve aerobic power. The little improvement of tolerance to higher workloads may be due to the antioxidant activity of CoQ10.
辅酶Q10（CoQ10）在氧化线粒体磷酸化中起重要作用，并可防止生物膜中的脂质过氧化。在持续体育锻炼期间，活性氧（ROS）通过多种机制产生增加；其中之一是在AMP分解过程中，通过将黄嘌呤脱氢酶转变为黄嘌呤氧化酶来激活嘌呤核苷酸循环。本研究的目的是评估CoQ10治疗对有氧能力的影响。
根据单盲研究设计，将28名健康男性自行车运动员随机分为两组（CoQ10组或安慰剂组），并接受为期八周的治疗；有5名退出者，仅对23名受试者进行了完整评估。在八周治疗开始前和结束时，自行车运动员接受心肺运动测试。
一个软件系统进行必要的计算以获得以下参数：摄氧量、二氧化碳产生量、分钟通气量、氧通气当量、二氧化碳通气当量、氧脉搏。最后确定氧峰值和无氧阈值。此外，在每次测试前和测试后立即测量血液中的肌苷、次黄嘌呤、黄嘌呤、乳酸和CoQ10水平。
本研究结果表明，在八周结束时，两组在生理和代谢参数方面没有差异，但CoQ10组在更高的工作量下才达到肌肉疲劳。
根据我们的经验，泛癸利酮口服治疗并不能提高有氧能力。对更高工作量耐受性的轻微改善可能归因于CoQ10的抗氧化活性。
