慢性吸烟者的体外淋巴细胞反应性和T细胞水平。
In vitro lymphocyte reactivity and T-cell levels in chronic cigarette smokers.
作者信息
Silverman N A, Potvin C, Alexander J C, Chretien P B
出版信息
Clin Exp Immunol. 1975 Nov;22(2):285-92.
Abstract
Peripheral blood total leucocyte, lymphocyte and thymus-dependent lymphocyte (T cell) levels and in vitro lymphocyte reactivity (LR) to phytohaemagglutinin (PHA) were determined in 153 chronic cigarette smokers and 115 non-smokers ranging in age from 20 to 78 years. Total leucocyte, lymphocyte and T-cell levels were significantly elevated in smokers. There was no correlation with age. LR to PHA was significantly higher in smokers less than 40 years of age or in those with a 20 pack-year or less history of cigarette consumption. Older smokers or those with a history of heavier cigarette consumption did not differ from normals. The results contrast with previous demonstrations of suppression of immune reactivity after exposure to tobacco products. The possible effects of the apparent stimulation of the lymphoid system by chromic cigarette consumption is considered.
摘要
对153名年龄在20至78岁之间的慢性吸烟者和115名不吸烟者测定了外周血总白细胞、淋巴细胞和胸腺依赖性淋巴细胞（T细胞）水平，以及体外淋巴细胞对植物血凝素（PHA）的反应性（LR）。吸烟者的总白细胞、淋巴细胞和T细胞水平显著升高。与年龄无关。40岁以下的吸烟者或吸烟史在20包年及以下的吸烟者对PHA的LR显著更高。年长的吸烟者或吸烟史更长的吸烟者与正常人没有差异。这些结果与之前关于接触烟草制品后免疫反应性受到抑制的证明形成对比。考虑了长期吸烟对淋巴系统明显刺激的可能影响。
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