Andersen P, Pedersen O F, Bach B, Bonde G J
Clin Exp Immunol. 1982 Feb;47(2):467-73.
Antibodies to antigens in humidifier water were detected by double immunodiffusion in 30 of 63 (47.6%) persons who were exposed to aerosols from a water humidification unit in a cigar plant, whereas no antibodies could be detected in 49 unexposed blood donors (P less than 0.001). The presence of antibodies could not be related to fever or pulmonary symptoms (cough, expectoration, dyspnoe). Antibodies were found in 14 (93.3%) of 15 nonsmokers and in only 13 (31.7%) of 41 smokers (P less than 0.001), and the titres were highest in nonsmokers. Serum IgG and IgA levels were higher in nonsmokers than in smokers, and the variances within the groups were significantly different (F less than 0.05 and F less than 0.05, respectively). The mean serum IgM values were not significantly different in the two groups. Antibodies to Candida albicans and Escherichia coli 04 and 075 were detected with equal prevalences and titres in smokers and nonsmokers. These findings suggest that tobacco smoking may suppress the humoral immune response to inhaled antigens but not to antigens which are supposed to be absorbed through membranes other than those of the bronchopulmonary system. They may partly explain the reported increased incidence of allergic alveolitis in nonsmokers.
在一家雪茄厂中，对63名接触水加湿装置产生的气溶胶的人员进行检测，通过双向免疫扩散法在其中30人（47.6%）体内检测到加湿器水中抗原的抗体，而在49名未接触的献血者中未检测到抗体（P<0.001）。抗体的存在与发热或肺部症状（咳嗽、咳痰、呼吸困难）无关。在15名不吸烟者中有14人（93.3%）检测到抗体，而在41名吸烟者中只有13人（31.7%）检测到抗体（P<0.001），且抗体滴度在不吸烟者中最高。不吸烟者血清IgG和IgA水平高于吸烟者，两组内方差有显著差异（分别为F<0.05和F<0.05）。两组的平均血清IgM值无显著差异。在吸烟者和不吸烟者中，白色念珠菌、大肠杆菌O4和O75抗体的检出率和滴度相同。这些发现表明，吸烟可能会抑制对吸入抗原的体液免疫反应，但不会抑制对预计通过支气管肺系统以外的膜吸收的抗原的免疫反应。它们可能部分解释了报道中不吸烟者变应性肺泡炎发病率增加的现象。
